2BXS
Human Monoamine Oxidase A in complex with Clorgyline, Crystal Form B
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006576 | biological_process | biogenic amine metabolic process |
| A | 0006584 | biological_process | catecholamine metabolic process |
| A | 0008131 | molecular_function | primary amine oxidase activity |
| A | 0009967 | biological_process | positive regulation of signal transduction |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042420 | biological_process | dopamine catabolic process |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0052595 | molecular_function | aliphatic amine oxidase activity |
| A | 0097621 | molecular_function | monoamine oxidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005741 | cellular_component | mitochondrial outer membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0006576 | biological_process | biogenic amine metabolic process |
| B | 0006584 | biological_process | catecholamine metabolic process |
| B | 0008131 | molecular_function | primary amine oxidase activity |
| B | 0009967 | biological_process | positive regulation of signal transduction |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042420 | biological_process | dopamine catabolic process |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0052595 | molecular_function | aliphatic amine oxidase activity |
| B | 0097621 | molecular_function | monoamine oxidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE FAD A 600 |
| Chain | Residue |
| A | ILE19 |
| A | GLY50 |
| A | ARG51 |
| A | GLY66 |
| A | GLY67 |
| A | ALA68 |
| A | TYR69 |
| A | HIS242 |
| A | PRO243 |
| A | VAL244 |
| A | ILE273 |
| A | GLY20 |
| A | TRP397 |
| A | TYR402 |
| A | CYS406 |
| A | TYR407 |
| A | GLY434 |
| A | THR435 |
| A | GLY443 |
| A | TYR444 |
| A | MET445 |
| A | MLG601 |
| A | GLY22 |
| A | ILE23 |
| A | SER24 |
| A | LEU42 |
| A | GLU43 |
| A | ALA44 |
| A | ARG45 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MLG A 601 |
| Chain | Residue |
| A | GLU216 |
| A | CYS323 |
| A | ILE335 |
| A | LEU337 |
| A | PHE352 |
| A | TYR407 |
| A | FAD600 |
| site_id | AC3 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE FAD B 600 |
| Chain | Residue |
| B | ILE19 |
| B | GLY20 |
| B | GLY22 |
| B | SER24 |
| B | LEU42 |
| B | GLU43 |
| B | ALA44 |
| B | GLY50 |
| B | ARG51 |
| B | GLY67 |
| B | ALA68 |
| B | TYR69 |
| B | HIS242 |
| B | PRO243 |
| B | VAL244 |
| B | ILE273 |
| B | TRP397 |
| B | TYR402 |
| B | CYS406 |
| B | TYR407 |
| B | GLY434 |
| B | THR435 |
| B | GLY443 |
| B | TYR444 |
| B | MET445 |
| B | MLG601 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MLG B 601 |
| Chain | Residue |
| B | GLU216 |
| B | CYS323 |
| B | ILE335 |
| B | LEU337 |
| B | PHE352 |
| B | TYR407 |
| B | FAD600 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 992 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:18391214 |
| Chain | Residue | Details |
| A | MET1-SER497 | |
| B | MET1-SER497 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Anchor for type IV membrane protein |
| Chain | Residue | Details |
| A | VAL498-LEU518 | |
| B | VAL498-LEU518 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:18391214 |
| Chain | Residue | Details |
| A | TYR519-SER527 | |
| B | TYR519-SER527 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Important for substrate specificity => ECO:0000250 |
| Chain | Residue | Details |
| A | ILE335 | |
| B | ILE335 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Important for catalytic activity |
| Chain | Residue | Details |
| A | CYS374 | |
| B | CYS374 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:11812236 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P21396 |
| Chain | Residue | Details |
| A | SER383 | |
| B | SER383 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: S-8alpha-FAD cysteine => ECO:0000269|PubMed:18391214, ECO:0007744|PDB:2BXR, ECO:0007744|PDB:2BXS, ECO:0007744|PDB:2Z5X, ECO:0007744|PDB:2Z5Y |
| Chain | Residue | Details |
| A | CYS406 | |
| B | CYS406 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1b5q |
| Chain | Residue | Details |
| A | GLY71 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1b5q |
| Chain | Residue | Details |
| B | GLY71 |
