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2BW0

Crystal Structure of the hydrolase domain of Human 10-Formyltetrahydrofolate 2 dehydrogenase

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0009058biological_processbiosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A1308
ChainResidue
AARG112
AASP127
ALYS128
ALYS129
AHOH2460
AHOH2461
AHOH2462
AHOH2463

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A1309
ChainResidue
AGLY197
AHOH2347
AHOH2464
AHOH2465
AARG112

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A1310
ChainResidue
AARG60
APRO91
AMET92
APRO264
AGLY265
AHOH2424
AHOH2467
AHOH2468
AHOH2469

Functional Information from PROSITE/UniProt
site_idPS00373
Number of Residues24
DetailsGART Phosphoribosylglycinamide formyltransferase active site. GfSIfWAdDgLDtGdlLlqkeceV
ChainResidueDetails
AGLY131-VAL154

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:P28037
ChainResidueDetails
AHIS106

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:17057331, ECO:0007744|PDB:2CFI
ChainResidueDetails
AGLN88
AASP142

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Essential for catalytic activity => ECO:0000250|UniProtKB:P28037
ChainResidueDetails
AASP142

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER9

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8R0Y6
ChainResidueDetails
ALYS38

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1c2t
ChainResidueDetails
AASP142
AILE104
ASER133
AHIS106

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1c2t
ChainResidueDetails
AASP142
AILE104
AHIS106

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1c2t
ChainResidueDetails
AASP142
AHIS106

226707

PDB entries from 2024-10-30

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