2BU8
crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004740 | molecular_function | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0005967 | cellular_component | obsolete mitochondrial pyruvate dehydrogenase complex |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006111 | biological_process | regulation of gluconeogenesis |
| A | 0006885 | biological_process | regulation of pH |
| A | 0008286 | biological_process | insulin receptor signaling pathway |
| A | 0010510 | biological_process | regulation of acetyl-CoA biosynthetic process from pyruvate |
| A | 0010565 | biological_process | regulation of cellular ketone metabolic process |
| A | 0010906 | biological_process | regulation of glucose metabolic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0031670 | biological_process | cellular response to nutrient |
| A | 0034614 | biological_process | cellular response to reactive oxygen species |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| A | 0050848 | biological_process | regulation of calcium-mediated signaling |
| A | 0072332 | biological_process | intrinsic apoptotic signaling pathway by p53 class mediator |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A1378 |
| Chain | Residue |
| A | GLU243 |
| A | ASN247 |
| A | ADP1377 |
| A | HOH2150 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADP A1377 |
| Chain | Residue |
| A | LEU295 |
| A | ALA316 |
| A | GLY317 |
| A | PHE318 |
| A | GLY319 |
| A | GLY321 |
| A | LEU322 |
| A | THR346 |
| A | MG1378 |
| A | HOH2101 |
| A | HOH2144 |
| A | HOH2145 |
| A | HOH2146 |
| A | HOH2147 |
| A | HOH2148 |
| A | HOH2151 |
| A | ASN247 |
| A | ARG250 |
| A | ALA251 |
| A | ASP282 |
| A | VAL287 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE TF4 A1379 |
| Chain | Residue |
| A | LEU53 |
| A | TYR80 |
| A | ILE111 |
| A | HIS115 |
| A | ARG154 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16401071 |
| Chain | Residue | Details |
| A | GLU243 | |
| A | ASP282 | |
| A | GLY317 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | SER301 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q15118 |
| Chain | Residue | Details |
| A | TYR207 | |
| A | TYR208 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8BFP9 |
| Chain | Residue | Details |
| A | LYS368 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1jm6 |
| Chain | Residue | Details |
| A | GLU243 | |
| A | HIS239 |
