Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2BR8

Crystal Structure of Acetylcholine-binding Protein (AChBP) from Aplysia californica in complex with an alpha-conotoxin PnIA variant

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005515molecular_functionprotein binding
A0006811biological_processmonoatomic ion transport
A0007165biological_processsignal transduction
A0007271biological_processsynaptic transmission, cholinergic
A0015464molecular_functionacetylcholine receptor activity
A0016020cellular_componentmembrane
A0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
A0034220biological_processmonoatomic ion transmembrane transport
A0035094biological_processresponse to nicotine
A0042391biological_processregulation of membrane potential
A0042802molecular_functionidentical protein binding
A0043005cellular_componentneuron projection
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0050877biological_processnervous system process
A0060078biological_processregulation of postsynaptic membrane potential
A0060079biological_processexcitatory postsynaptic potential
A0098794cellular_componentpostsynapse
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005515molecular_functionprotein binding
B0006811biological_processmonoatomic ion transport
B0007165biological_processsignal transduction
B0007271biological_processsynaptic transmission, cholinergic
B0015464molecular_functionacetylcholine receptor activity
B0016020cellular_componentmembrane
B0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
B0034220biological_processmonoatomic ion transmembrane transport
B0035094biological_processresponse to nicotine
B0042391biological_processregulation of membrane potential
B0042802molecular_functionidentical protein binding
B0043005cellular_componentneuron projection
B0045202cellular_componentsynapse
B0046872molecular_functionmetal ion binding
B0050877biological_processnervous system process
B0060078biological_processregulation of postsynaptic membrane potential
B0060079biological_processexcitatory postsynaptic potential
B0098794cellular_componentpostsynapse
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005515molecular_functionprotein binding
C0006811biological_processmonoatomic ion transport
C0007165biological_processsignal transduction
C0007271biological_processsynaptic transmission, cholinergic
C0015464molecular_functionacetylcholine receptor activity
C0016020cellular_componentmembrane
C0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
C0034220biological_processmonoatomic ion transmembrane transport
C0035094biological_processresponse to nicotine
C0042391biological_processregulation of membrane potential
C0042802molecular_functionidentical protein binding
C0043005cellular_componentneuron projection
C0045202cellular_componentsynapse
C0046872molecular_functionmetal ion binding
C0050877biological_processnervous system process
C0060078biological_processregulation of postsynaptic membrane potential
C0060079biological_processexcitatory postsynaptic potential
C0098794cellular_componentpostsynapse
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005515molecular_functionprotein binding
D0006811biological_processmonoatomic ion transport
D0007165biological_processsignal transduction
D0007271biological_processsynaptic transmission, cholinergic
D0015464molecular_functionacetylcholine receptor activity
D0016020cellular_componentmembrane
D0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
D0034220biological_processmonoatomic ion transmembrane transport
D0035094biological_processresponse to nicotine
D0042391biological_processregulation of membrane potential
D0042802molecular_functionidentical protein binding
D0043005cellular_componentneuron projection
D0045202cellular_componentsynapse
D0046872molecular_functionmetal ion binding
D0050877biological_processnervous system process
D0060078biological_processregulation of postsynaptic membrane potential
D0060079biological_processexcitatory postsynaptic potential
D0098794cellular_componentpostsynapse
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005515molecular_functionprotein binding
E0006811biological_processmonoatomic ion transport
E0007165biological_processsignal transduction
E0007271biological_processsynaptic transmission, cholinergic
E0015464molecular_functionacetylcholine receptor activity
E0016020cellular_componentmembrane
E0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
E0034220biological_processmonoatomic ion transmembrane transport
E0035094biological_processresponse to nicotine
E0042391biological_processregulation of membrane potential
E0042802molecular_functionidentical protein binding
E0043005cellular_componentneuron projection
E0045202cellular_componentsynapse
E0046872molecular_functionmetal ion binding
E0050877biological_processnervous system process
E0060078biological_processregulation of postsynaptic membrane potential
E0060079biological_processexcitatory postsynaptic potential
E0098794cellular_componentpostsynapse
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0030550molecular_functionacetylcholine receptor inhibitor activity
F0035792cellular_componenthost cell postsynaptic membrane
F0035821biological_processmodulation of process of another organism
F0090729molecular_functiontoxin activity
F0099106molecular_functionion channel regulator activity
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0030550molecular_functionacetylcholine receptor inhibitor activity
G0035792cellular_componenthost cell postsynaptic membrane
G0035821biological_processmodulation of process of another organism
G0090729molecular_functiontoxin activity
G0099106molecular_functionion channel regulator activity
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0030550molecular_functionacetylcholine receptor inhibitor activity
H0035792cellular_componenthost cell postsynaptic membrane
H0035821biological_processmodulation of process of another organism
H0090729molecular_functiontoxin activity
H0099106molecular_functionion channel regulator activity
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0030550molecular_functionacetylcholine receptor inhibitor activity
I0035792cellular_componenthost cell postsynaptic membrane
I0035821biological_processmodulation of process of another organism
I0090729molecular_functiontoxin activity
I0099106molecular_functionion channel regulator activity
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0030550molecular_functionacetylcholine receptor inhibitor activity
J0035792cellular_componenthost cell postsynaptic membrane
J0035821biological_processmodulation of process of another organism
J0090729molecular_functiontoxin activity
J0099106molecular_functionion channel regulator activity
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 C1206
ChainResidue
CTYR186
CSER187
CCYS188
CHOH2059
HGLY1
HCYS2
HTYR15
HHOH2001

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 E1206
ChainResidue
ESER187
ECYS188
JGLY1
JCYS2
JTYR15
ETYR186

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 F1018
ChainResidue
ATYR186
ACYS188
FGLY1
FCYS2
FTYR15

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 G1018
ChainResidue
BTYR186
BSER187
BCYS188
GGLY1
GCYS2
GTYR15
GHOH2004

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 I1018
ChainResidue
DTYR186
DSER187
DCYS188
IGLY1
ICYS2
ITYR15

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsSITE: Important for inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 nAChR; interacts with a hydrophobic pocket between the two alpha-7/CHRNA7 subunits or between the alpha-3 and the beta-2 subunits of alpha-3-beta-2/CHRNA3-CHRNB2 nAChR => ECO:0000305|PubMed:10545176, ECO:0000305|PubMed:25101833
ChainResidueDetails
FLEU10
GLEU10
HLEU10
ILEU10
JLEU10

site_idSWS_FT_FI2
Number of Residues5
DetailsSITE: Important for inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-7/CHRNA7 nAChR => ECO:0000305|PubMed:10545176
ChainResidueDetails
FASN11
GASN11
HASN11
IASN11
JASN11

site_idSWS_FT_FI3
Number of Residues5
DetailsMOD_RES: Sulfotyrosine => ECO:0000269|PubMed:10226369
ChainResidueDetails
FTYR15
GTYR15
HTYR15
ITYR15
JTYR15

site_idSWS_FT_FI4
Number of Residues5
DetailsMOD_RES: Cysteine amide => ECO:0000269|PubMed:8068627
ChainResidueDetails
FCYS16
GCYS16
HCYS16
ICYS16
JCYS16

222036

PDB entries from 2024-07-03

PDB statisticsPDBj update infoContact PDBjnumon