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2BR0

DNA Adduct Bypass Polymerization by Sulfolobus solfataricus Dpo4. Analysis and Crystal Structures of Multiple Base-Pair Substitution and Frameshift Products with the Adduct 1,N2-Ethenoguanine

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0005737cellular_componentcytoplasm
A0006260biological_processDNA replication
A0006261biological_processDNA-templated DNA replication
A0006281biological_processDNA repair
A0006974biological_processDNA damage response
A0042276biological_processerror-prone translesion synthesis
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A2001
ChainResidue
AASP7
AASP105
AGLU106
ACA2002

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A2002
ChainResidue
AASP7
APHE8
AASP105
ACA2001

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A2003
ChainResidue
AILE186
AHOH2053
PHOH2004
PHOH2013
PHOH2014
AALA181

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE:
ChainResidueDetails
AGLU106

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING:
ChainResidueDetails
AASP7
AASP105

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Substrate discrimination
ChainResidueDetails
ATYR12

226707

PDB entries from 2024-10-30

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