2BNF

The structure of E. coli UMP kinase in complex with UTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006225	biological_process	UDP biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0033862	molecular_function	UMP kinase activity
A	0042802	molecular_function	identical protein binding
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0046940	biological_process	nucleoside monophosphate phosphorylation
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006225	biological_process	UDP biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0033862	molecular_function	UMP kinase activity
B	0042802	molecular_function	identical protein binding
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0046940	biological_process	nucleoside monophosphate phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE UTP A1242

Chain	Residue
A	LYS15
A	ASP77
A	GLY80
A	MSE81
A	THR138
A	ASN140
A	PRO141
A	PHE143
A	THR144
A	THR145
A	HOH2009
A	SER17
A	HOH2040
A	GLY18
A	GLY56
A	GLY57
A	GLY58
A	PHE61
A	ARG62
A	GLY63

---

site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE UTP B1242

Chain	Residue
B	LYS15
B	SER17
B	GLY18
B	GLU19
B	GLY56
B	GLY57
B	GLY58
B	PHE61
B	ARG62
B	GLY63
B	ASP77
B	GLY80
B	MSE81
B	THR138
B	ASN140
B	PRO141
B	PHE143
B	THR144
B	THR145
B	HOH2012
B	HOH2025

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A1243

Chain	Residue
A	GLN39
A	LYS42
A	GOL1244
B	GLN39
B	GLU46

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A1244

Chain	Residue
A	GLN39
A	GLU46
A	GOL1243
B	GLN39
B	LYS42

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A1245

Chain	Residue
A	GLY58
A	LEU60
A	PHE61
A	ARG62

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A1246

Chain	Residue
A	VAL192
A	LEU193
A	LEU197
A	VAL199
A	MSE200
A	LEU202
A	HOH2033

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A1247

Chain	Residue
A	VAL100
A	ASN101
A	ARG127
A	HOH2041

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B1243

Chain	Residue
A	ASP210
A	HIS211
B	ARG73

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B1244

Chain	Residue
B	VAL100
B	ASN101
B	HOH2033

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Region: {"description":"Involved in allosteric activation by GTP","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15857829","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18945668","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BND","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2V4Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15857829","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BND","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15857829","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18945668","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BNE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2V4Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18945668","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V4Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15857829","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18945668","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BND","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2V4Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---