2BKX
Structure and kinetics of a monomeric glucosamine-6-phosphate deaminase: missing link of the NagB superfamily
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004342 | molecular_function | glucosamine-6-phosphate deaminase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006043 | biological_process | glucosamine catabolic process |
| A | 0006044 | biological_process | N-acetylglucosamine metabolic process |
| A | 0006046 | biological_process | N-acetylglucosamine catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0004342 | molecular_function | glucosamine-6-phosphate deaminase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006043 | biological_process | glucosamine catabolic process |
| B | 0006044 | biological_process | N-acetylglucosamine metabolic process |
| B | 0006046 | biological_process | N-acetylglucosamine catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE F6R A1243 |
| Chain | Residue |
| A | ALA35 |
| A | HIS138 |
| A | GLY140 |
| A | ARG167 |
| A | LYS202 |
| A | HOH2123 |
| A | HOH2230 |
| A | HOH2361 |
| A | HOH2362 |
| A | HOH2363 |
| A | HOH2364 |
| A | THR36 |
| A | HOH2365 |
| A | HOH2366 |
| A | GLY37 |
| A | GLY38 |
| A | THR39 |
| A | LEU66 |
| A | ASP67 |
| A | GLY132 |
| A | ILE133 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE F6R B1243 |
| Chain | Residue |
| B | ALA35 |
| B | THR36 |
| B | GLY37 |
| B | GLY38 |
| B | THR39 |
| B | LEU66 |
| B | ASP67 |
| B | GLY132 |
| B | ILE133 |
| B | HIS138 |
| B | GLY140 |
| B | ARG167 |
| B | LYS202 |
| B | HOH2126 |
| B | HOH2230 |
| B | HOH2359 |
| B | HOH2360 |
| B | HOH2361 |
| B | HOH2362 |
| B | HOH2363 |
| B | HOH2364 |
Functional Information from PROSITE/UniProt
| site_id | PS01161 |
| Number of Residues | 19 |
| Details | GLC_GALNAC_ISOMERASE Glucosamine/galactosamine-6-phosphate isomerases signature. VdslGdTdIqLlGIGrNGH |
| Chain | Residue | Details |
| A | VAL120-HIS138 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor; for enolization step => ECO:0000255|HAMAP-Rule:MF_01241 |
| Chain | Residue | Details |
| A | ASP67 | |
| B | ASP67 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: For ring-opening step => ECO:0000255|HAMAP-Rule:MF_01241 |
| Chain | Residue | Details |
| A | ASN136 | |
| A | GLU143 | |
| B | ASN136 | |
| B | GLU143 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor; for ring-opening step => ECO:0000255|HAMAP-Rule:MF_01241 |
| Chain | Residue | Details |
| A | HIS138 | |
| B | HIS138 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15755726, ECO:0007744|PDB:2BKX |
| Chain | Residue | Details |
| A | THR36 | |
| B | GLY38 | |
| B | THR39 | |
| B | ASP67 | |
| B | HIS138 | |
| B | GLY140 | |
| B | ARG167 | |
| B | LYS202 | |
| A | GLY38 | |
| A | THR39 | |
| A | ASP67 | |
| A | HIS138 | |
| A | GLY140 | |
| A | ARG167 | |
| A | LYS202 | |
| B | THR36 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cd5 |
| Chain | Residue | Details |
| A | ASN136 | |
| A | HIS138 | |
| A | GLU143 | |
| A | ASP67 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cd5 |
| Chain | Residue | Details |
| B | ASN136 | |
| B | HIS138 | |
| B | GLU143 | |
| B | ASP67 |
