2BJI
High Resolution Structure of myo-Inositol Monophosphatase, The Target of Lithium Therapy
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004346 | molecular_function | glucose-6-phosphatase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006020 | biological_process | inositol metabolic process |
| A | 0006021 | biological_process | inositol biosynthetic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0008877 | molecular_function | glucose-1-phosphatase activity |
| A | 0008934 | molecular_function | inositol monophosphate 1-phosphatase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0031403 | molecular_function | lithium ion binding |
| A | 0046854 | biological_process | phosphatidylinositol phosphate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047954 | molecular_function | glycerol-2-phosphatase activity |
| A | 0052832 | molecular_function | inositol monophosphate 3-phosphatase activity |
| A | 0052833 | molecular_function | inositol monophosphate 4-phosphatase activity |
| A | 0052834 | molecular_function | inositol monophosphate phosphatase activity |
| A | 0103026 | molecular_function | fructose-1-phosphatase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004346 | molecular_function | glucose-6-phosphatase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006020 | biological_process | inositol metabolic process |
| B | 0006021 | biological_process | inositol biosynthetic process |
| B | 0007165 | biological_process | signal transduction |
| B | 0008877 | molecular_function | glucose-1-phosphatase activity |
| B | 0008934 | molecular_function | inositol monophosphate 1-phosphatase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0031403 | molecular_function | lithium ion binding |
| B | 0046854 | biological_process | phosphatidylinositol phosphate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047954 | molecular_function | glycerol-2-phosphatase activity |
| B | 0052832 | molecular_function | inositol monophosphate 3-phosphatase activity |
| B | 0052833 | molecular_function | inositol monophosphate 4-phosphatase activity |
| B | 0052834 | molecular_function | inositol monophosphate phosphatase activity |
| B | 0103026 | molecular_function | fructose-1-phosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG A2277 |
| Chain | Residue |
| A | GLU1070 |
| A | ASP1090 |
| A | ILE1092 |
| A | HOH2081 |
| A | HOH2082 |
| A | HOH2086 |
| A | MG2278 |
| A | MG2279 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A2278 |
| Chain | Residue |
| A | ASP1093 |
| A | ASP1220 |
| A | HOH2081 |
| A | HOH2083 |
| A | HOH2184 |
| A | MG2277 |
| A | ASP1090 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A2279 |
| Chain | Residue |
| A | GLU1070 |
| A | HOH2033 |
| A | HOH2034 |
| A | HOH2064 |
| A | HOH2066 |
| A | HOH2086 |
| A | MG2277 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B3277 |
| Chain | Residue |
| B | GLU2070 |
| B | ASP2090 |
| B | ILE2092 |
| B | HOH3103 |
| B | HOH3127 |
| B | HOH3130 |
| B | MG3278 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B3278 |
| Chain | Residue |
| B | ASP2090 |
| B | ASP2093 |
| B | ASP2220 |
| B | HOH3127 |
| B | HOH3223 |
| B | MG3277 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B3279 |
| Chain | Residue |
| B | GLU2070 |
| B | HOH3077 |
| B | HOH3078 |
| B | HOH3105 |
| B | HOH3107 |
| B | HOH3130 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P29218 |
| Chain | Residue | Details |
| A | GLU1070 | |
| A | GLY1194 | |
| A | GLU1213 | |
| A | ASP1220 | |
| B | GLU2070 | |
| B | GLY2194 | |
| B | GLU2213 | |
| B | ASP2220 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15858264 |
| Chain | Residue | Details |
| A | ASP1090 | |
| A | ILE1092 | |
| A | ASP1093 | |
| B | ASP2090 | |
| B | ILE2092 | |
| B | ASP2093 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P29218 |
| Chain | Residue | Details |
| A | THR1168 | |
| B | THR2168 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ima |
| Chain | Residue | Details |
| A | THR1095 | |
| A | GLU1070 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ima |
| Chain | Residue | Details |
| B | GLU2070 | |
| B | THR2095 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ima |
| Chain | Residue | Details |
| A | THR1095 | |
| A | ASP1220 | |
| A | ASP1047 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ima |
| Chain | Residue | Details |
| B | ASP2047 | |
| B | THR2095 | |
| B | ASP2220 |
