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2BHL

X-RAY STRUCTURE OF HUMAN GLUCOSE-6-PHOSPHATE DEHYDROGENASE (DELETION VARIANT) COMPLEXED WITH GLUCOSE-6-PHOSPHATE

Functional Information from GO Data
ChainGOidnamespacecontents
A0004345molecular_functionglucose-6-phosphate dehydrogenase activity
A0005515molecular_functionprotein binding
A0005536molecular_functionglucose binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006006biological_processglucose metabolic process
A0006098biological_processpentose-phosphate shunt
A0006629biological_processlipid metabolic process
A0006695biological_processcholesterol biosynthetic process
A0006739biological_processNADP metabolic process
A0006740biological_processNADPH regeneration
A0006749biological_processglutathione metabolic process
A0009051biological_processpentose-phosphate shunt, oxidative branch
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010041biological_processresponse to iron(III) ion
A0010734biological_processnegative regulation of protein glutathionylation
A0014070biological_processresponse to organic cyclic compound
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
A0019322biological_processpentose biosynthetic process
A0021762biological_processsubstantia nigra development
A0030246molecular_functioncarbohydrate binding
A0032094biological_processresponse to food
A0034451cellular_componentcentriolar satellite
A0034599biological_processcellular response to oxidative stress
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043231cellular_componentintracellular membrane-bounded organelle
A0043249biological_processerythrocyte maturation
A0043523biological_processregulation of neuron apoptotic process
A0045471biological_processresponse to ethanol
A0046390biological_processribose phosphate biosynthetic process
A0050661molecular_functionNADP binding
A0051156biological_processglucose 6-phosphate metabolic process
A0061052biological_processnegative regulation of cell growth involved in cardiac muscle cell development
A0070062cellular_componentextracellular exosome
A1904879biological_processpositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
A2000378biological_processnegative regulation of reactive oxygen species metabolic process
B0004345molecular_functionglucose-6-phosphate dehydrogenase activity
B0005515molecular_functionprotein binding
B0005536molecular_functionglucose binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006006biological_processglucose metabolic process
B0006098biological_processpentose-phosphate shunt
B0006629biological_processlipid metabolic process
B0006695biological_processcholesterol biosynthetic process
B0006739biological_processNADP metabolic process
B0006740biological_processNADPH regeneration
B0006749biological_processglutathione metabolic process
B0009051biological_processpentose-phosphate shunt, oxidative branch
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010041biological_processresponse to iron(III) ion
B0010734biological_processnegative regulation of protein glutathionylation
B0014070biological_processresponse to organic cyclic compound
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
B0019322biological_processpentose biosynthetic process
B0021762biological_processsubstantia nigra development
B0030246molecular_functioncarbohydrate binding
B0032094biological_processresponse to food
B0034451cellular_componentcentriolar satellite
B0034599biological_processcellular response to oxidative stress
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043231cellular_componentintracellular membrane-bounded organelle
B0043249biological_processerythrocyte maturation
B0043523biological_processregulation of neuron apoptotic process
B0045471biological_processresponse to ethanol
B0046390biological_processribose phosphate biosynthetic process
B0050661molecular_functionNADP binding
B0051156biological_processglucose 6-phosphate metabolic process
B0061052biological_processnegative regulation of cell growth involved in cardiac muscle cell development
B0070062cellular_componentextracellular exosome
B1904879biological_processpositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
B2000378biological_processnegative regulation of reactive oxygen species metabolic process
Functional Information from PROSITE/UniProt
site_idPS00069
Number of Residues7
DetailsG6P_DEHYDROGENASE Glucose-6-phosphate dehydrogenase active site. DHYLGKE
ChainResidueDetails
AASP200-GLU206

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P11411
ChainResidueDetails
ALEU264
BLEU264

site_idSWS_FT_FI2
Number of Residues24
DetailsBINDING: BINDING => ECO:0000269|PubMed:10745013, ECO:0000269|PubMed:15858258, ECO:0007744|PDB:1QKI, ECO:0007744|PDB:2BH9
ChainResidueDetails
AALA39
AGLY488
AGLU504
AVAL510
BALA39
BSER73
BGLU148
BCYS358
BALA367
BLEU371
BVAL394
ASER73
BTHR402
BLEU422
BGLY488
BGLU504
BVAL510
AGLU148
ACYS358
AALA367
ALEU371
AVAL394
ATHR402
ALEU422

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:15858258, ECO:0007744|PDB:2BH9
ChainResidueDetails
APRO172
ATYR202
APRO240
AVAL259
BPRO172
BTYR202
BPRO240
BVAL259

site_idSWS_FT_FI4
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:15858258, ECO:0007744|PDB:2BHL
ChainResidueDetails
AALA361
ALYS366
APRO396
BALA361
BLYS366
BPRO396

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
AALA90
ALEU433
AARG498
BALA90
BLEU433
BARG498

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
APRO172
BPRO172

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:24769394, ECO:0007744|PubMed:19608861
ChainResidueDetails
AMET404
BMET404

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
AGLU504
BGLU504

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1dpg
ChainResidueDetails
AASP200
AHIS263

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1dpg
ChainResidueDetails
BASP200
BHIS263

219140

PDB entries from 2024-05-01

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