2BHG

3C protease from type A10(61) foot-and-mouth disease virus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: For protease 3C activity; Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01222, ECO:0000269|PubMed:15654079

Chain	Residue	Details
A	HIS46
B	HIS46

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: For protease 3C activity => ECO:0000255|PROSITE-ProRule:PRU01222, ECO:0000269|PubMed:15654079

Chain	Residue	Details
A	ASP84
A	TYR162
B	ASP84
B	TYR162

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Important for catalytic activity => ECO:0007744|PDB:2BHG

Chain	Residue	Details
A	HIS181
B	HIS181

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	a catalytic site defined by CSA, PubMed 15654079

Chain	Residue	Details
A	HIS46

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 763

Chain	Residue	Details
A	HIS46	proton shuttle (general acid/base)
A	ASP84	electrostatic stabiliser
A	TYR162	covalent catalysis
A	HIS181	electrostatic stabiliser

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 763

Chain	Residue	Details
B	HIS46	proton shuttle (general acid/base)
B	ASP84	electrostatic stabiliser
B	TYR162	covalent catalysis
B	HIS181	electrostatic stabiliser

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