2BH9
X-RAY STRUCTURE OF A DELETION VARIANT OF HUMAN GLUCOSE 6-PHOSPHATE DEHYDROGENASE COMPLEXED WITH STRUCTURAL AND COENZYME NADP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004345 | molecular_function | glucose-6-phosphate dehydrogenase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005536 | molecular_function | D-glucose binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006006 | biological_process | glucose metabolic process |
A | 0006098 | biological_process | pentose-phosphate shunt |
A | 0006629 | biological_process | lipid metabolic process |
A | 0006695 | biological_process | cholesterol biosynthetic process |
A | 0006739 | biological_process | NADP metabolic process |
A | 0006740 | biological_process | NADPH regeneration |
A | 0006749 | biological_process | glutathione metabolic process |
A | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
A | 0010041 | biological_process | response to iron(III) ion |
A | 0010734 | biological_process | negative regulation of protein glutathionylation |
A | 0014070 | biological_process | response to organic cyclic compound |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
A | 0019322 | biological_process | pentose biosynthetic process |
A | 0021762 | biological_process | substantia nigra development |
A | 0030246 | molecular_function | carbohydrate binding |
A | 0032094 | biological_process | response to food |
A | 0034451 | cellular_component | centriolar satellite |
A | 0034599 | biological_process | cellular response to oxidative stress |
A | 0042802 | molecular_function | identical protein binding |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
A | 0043249 | biological_process | erythrocyte maturation |
A | 0043523 | biological_process | regulation of neuron apoptotic process |
A | 0045471 | biological_process | response to ethanol |
A | 0046390 | biological_process | ribose phosphate biosynthetic process |
A | 0050661 | molecular_function | NADP binding |
A | 0051156 | biological_process | glucose 6-phosphate metabolic process |
A | 0061052 | biological_process | negative regulation of cell growth involved in cardiac muscle cell development |
A | 0070062 | cellular_component | extracellular exosome |
A | 1904879 | biological_process | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
A | 2000378 | biological_process | negative regulation of reactive oxygen species metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE NAP A 799 |
Chain | Residue |
A | GLY38 |
A | ASP114 |
A | ALA141 |
A | LEU142 |
A | PRO143 |
A | TYR147 |
A | GLU170 |
A | LYS171 |
A | HOH2154 |
A | HOH2155 |
A | SER40 |
A | GLY41 |
A | ASP42 |
A | LEU43 |
A | ARG72 |
A | SER73 |
A | GLN111 |
A | TYR112 |
site_id | AC2 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE NAP A 811 |
Chain | Residue |
A | LYS238 |
A | LYS366 |
A | ARG370 |
A | ARG393 |
A | TYR401 |
A | LYS403 |
A | ASP421 |
A | THR423 |
A | ARG487 |
A | ASP493 |
A | PHE501 |
A | TYR503 |
A | TYR507 |
A | TRP509 |
A | HOH2152 |
A | HOH2157 |
A | HOH2159 |
A | HOH2161 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A1516 |
Chain | Residue |
A | GLY248 |
A | TYR249 |
A | GLU252 |
A | THR327 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A1517 |
Chain | Residue |
A | PRO467 |
A | GLN471 |
A | LEU474 |
A | HOH2162 |
Functional Information from PROSITE/UniProt
site_id | PS00069 |
Number of Residues | 7 |
Details | G6P_DEHYDROGENASE Glucose-6-phosphate dehydrogenase active site. DHYLGKE |
Chain | Residue | Details |
A | ASP200-GLU206 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P11411 |
Chain | Residue | Details |
A | LEU264 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10745013, ECO:0000269|PubMed:15858258, ECO:0007744|PDB:1QKI, ECO:0007744|PDB:2BH9 |
Chain | Residue | Details |
A | ALA39 | |
A | GLY488 | |
A | GLU504 | |
A | VAL510 | |
A | SER73 | |
A | GLU148 | |
A | CYS358 | |
A | ALA367 | |
A | LEU371 | |
A | VAL394 | |
A | THR402 | |
A | LEU422 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15858258, ECO:0007744|PDB:2BH9 |
Chain | Residue | Details |
A | PRO172 | |
A | TYR202 | |
A | PRO240 | |
A | VAL259 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15858258, ECO:0007744|PDB:2BHL |
Chain | Residue | Details |
A | ALA361 | |
A | LYS366 | |
A | PRO396 |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | ALA90 | |
A | LEU433 | |
A | ARG498 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | PRO172 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:24769394, ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | MET404 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | GLU504 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dpg |
Chain | Residue | Details |
A | ASP200 | |
A | HIS263 |