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2BDW

Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGAFSVVRrCvhkttgle..........FAAK
ChainResidueDetails
ALEU19-LYS42

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000305
ChainResidueDetails
AASN135
BASN135

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU19
BLEU19

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:20139983
ChainResidueDetails
ALYS42
BLYS42

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:16325579
ChainResidueDetails
ATHR286
BTHR286

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 2phk
ChainResidueDetails
AASN135
ALYS137

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 2phk
ChainResidueDetails
BASN135
BLYS137

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 2phk
ChainResidueDetails
AASN135
ALYS137
ATHR176

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 2phk
ChainResidueDetails
BASN135
BLYS137
BTHR176

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 2phk
ChainResidueDetails
AASN135
AASN140
ALYS137

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 2phk
ChainResidueDetails
BASN135
BASN140
BLYS137

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PDB entries from 2024-11-06

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