Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0022617 | biological_process | extracellular matrix disassembly |
| A | 0030141 | cellular_component | secretory granule |
| A | 0031214 | biological_process | biomineral tissue development |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051604 | biological_process | protein maturation |
| A | 0097186 | biological_process | amelogenesis |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0022617 | biological_process | extracellular matrix disassembly |
| B | 0030141 | cellular_component | secretory granule |
| B | 0031214 | biological_process | biomineral tissue development |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051604 | biological_process | protein maturation |
| B | 0097186 | biological_process | amelogenesis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 401 |
| Chain | Residue |
| A | LEU99 |
| A | ASP102 |
| A | MET180 |
| A | SER214 |
| A | HOH412 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 402 |
| Chain | Residue |
| A | CYS232 |
| A | PRO129 |
| A | GLN210 |
| A | ASN230 |
| A | LEU231 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 403 |
| Chain | Residue |
| B | LEU98 |
| B | SER164 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 404 |
| Chain | Residue |
| A | LEU98 |
| A | VAL163 |
| A | SER164 |
| A | VAL167 |
| A | HOH498 |
| A | HOH529 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NI A 405 |
| Chain | Residue |
| A | HIS25 |
| A | GLU77 |
| A | HOH480 |
| A | HOH483 |
| A | HOH486 |
| A | HOH557 |
| A | HOH563 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NI B 406 |
| Chain | Residue |
| B | HIS25 |
| B | GLU77 |
| B | HOH534 |
| B | HOH535 |
| B | HOH536 |
| B | HOH537 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI B 407 |
| Chain | Residue |
| B | THR64 |
| B | HOH538 |
| B | HOH539 |
| B | HOH540 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NI A 408 |
| Chain | Residue |
| A | ASN37 |
| A | HOH531 |
| A | HOH550 |
| A | HOH556 |
| A | HOH558 |
| A | HOH560 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PBZ A 301 |
| Chain | Residue |
| A | ASP189 |
| A | SER190 |
| A | ASN192 |
| A | SER195 |
| A | VAL213 |
| A | PHE215 |
| A | CYS220 |
| A | GLY226 |
| A | HOH424 |
| site_id | BC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PBZ B 302 |
| Chain | Residue |
| B | ASP189 |
| B | SER190 |
| B | SER195 |
| B | VAL213 |
| B | PHE215 |
| B | GLY216 |
| B | LYS217 |
| B | CYS220 |
| B | GLY226 |
| B | HOH415 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC |
| Chain | Residue | Details |
| A | LEU53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScnGDSGGPLI |
| Chain | Residue | Details |
| A | ASP189-ILE200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 442 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"16950394","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16950394","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS57 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | HIS57 | |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER195 | |
| A | ALA100 | |
| A | HIS57 | |
| A | GLY196 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER195 | |
| B | ALA100 | |
| B | HIS57 | |
| B | GLY196 | |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | GLY193 | |
| A | HIS57 | |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | GLY193 | |
| B | HIS57 | |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS57 | |
| A | GLY196 | |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | HIS57 | |
| B | GLY196 | |
