2BCS

DNA polymerase lambda in complex with a DNA duplex containing an unpaired Dcmp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 900

Chain	Residue
A	ASP427
A	ASP429
A	PPV901
A	HOH1006
P	DG7

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 600

Chain	Residue
P	HOH52
P	HOH180
A	SER339
A	ILE341
A	ALA344
P	DA5

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 620

Chain	Residue
A	SER463
A	HOH954
A	HOH993
A	HOH1002
T	HOH39
T	HOH44

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site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PPV A 901

Chain	Residue
A	ARG386
A	GLY416
A	SER417
A	ARG420
A	GLY426
A	ASP427
A	ASP429
A	MG900
A	HOH914
A	HOH984
A	HOH989
A	HOH1006
A	HOH1085
P	DG7

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865

Chain	Residue	Details
A	LYS312

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
A	ARG386
A	SER417
A	GLY426
A	ASN513

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
A	ASP427
A	ASP429
A	ASP490

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