2BCQ

DNA polymerase lambda in complex with a DNA duplex containing an unpaired Dtmp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 1

Chain	Residue
A	SER339
A	ILE341
A	ALA344
A	HOH2815
P	DA5
P	HOH37

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 4

Chain	Residue
A	HOH2927
A	HOH3042
T	HOH25
A	SER463
A	HOH2833
A	HOH2875

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 712

Chain	Residue
A	HOH2833
A	HOH3228
T	HOH55
T	HOH58
T	HOH80

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 713

Chain	Residue
A	ASP427
A	ASP429
A	PPV738
P	DG7

---

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PPV A 738

Chain	Residue
A	ARG386
A	GLY416
A	SER417
A	ARG420
A	GLY426
A	ASP427
A	ASP429
A	MG713
A	HOH2809
A	HOH2896
A	HOH2903
A	HOH2914
A	HOH2993
A	HOH3072
P	DG7

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 2801

Chain	Residue
A	GLN471
A	VAL494
A	HIS530
A	HOH2813
A	HOH2844
A	HOH2850

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Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865

Chain	Residue	Details
A	LYS312

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
A	ARG386
A	SER417
A	GLY426
A	ASN513

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
A	ASP427
A	ASP429
A	ASP490

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
A	ASP490

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