2BC9
Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with non-hydrolysable GTP analogue GppNHp
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 595 |
| Chain | Residue |
| A | SER52 |
| A | THR75 |
| A | GNP593 |
| A | HOH631 |
| A | HOH632 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE GNP A 593 |
| Chain | Residue |
| A | LYS51 |
| A | SER52 |
| A | TYR53 |
| A | LEU67 |
| A | GLY68 |
| A | SER69 |
| A | HIS74 |
| A | THR75 |
| A | GLY100 |
| A | ARG183 |
| A | ASP184 |
| A | SER186 |
| A | PRO241 |
| A | LEU247 |
| A | ALA248 |
| A | LEU250 |
| A | MG595 |
| A | HOH605 |
| A | HOH609 |
| A | HOH612 |
| A | HOH631 |
| A | HOH632 |
| A | TYR47 |
| A | ARG48 |
| A | THR49 |
| A | GLY50 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10676968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10970849","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16511497","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2B8W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2B92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D4H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10676968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10970849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F5N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PIM1","evidences":[{"source":"PubMed","id":"37797010","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"29144452","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
