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2BBW

Crystal structure of human adenylate kinase 4 (AK4) in complex with diguanosine pentaphosphate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002082biological_processregulation of oxidative phosphorylation
A0004017molecular_functionadenylate kinase activity
A0004550molecular_functionnucleoside diphosphate kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006139biological_processnucleobase-containing compound metabolic process
A0006172biological_processADP biosynthetic process
A0009117biological_processnucleotide metabolic process
A0009123biological_processnucleoside monophosphate metabolic process
A0009142biological_processnucleoside triphosphate biosynthetic process
A0009188biological_processribonucleoside diphosphate biosynthetic process
A0015949biological_processnucleobase-containing small molecule interconversion
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016740molecular_functiontransferase activity
A0016776molecular_functionphosphotransferase activity, phosphate group as acceptor
A0019205molecular_functionnucleobase-containing compound kinase activity
A0043231cellular_componentintracellular membrane-bounded organelle
A0046033biological_processAMP metabolic process
A0046034biological_processATP metabolic process
A0046039biological_processGTP metabolic process
A0046899molecular_functionnucleoside triphosphate adenylate kinase activity
A0046940biological_processnucleoside monophosphate phosphorylation
A0050145molecular_functionnucleoside monophosphate kinase activity
A0071456biological_processcellular response to hypoxia
B0000166molecular_functionnucleotide binding
B0002082biological_processregulation of oxidative phosphorylation
B0004017molecular_functionadenylate kinase activity
B0004550molecular_functionnucleoside diphosphate kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006139biological_processnucleobase-containing compound metabolic process
B0006172biological_processADP biosynthetic process
B0009117biological_processnucleotide metabolic process
B0009123biological_processnucleoside monophosphate metabolic process
B0009142biological_processnucleoside triphosphate biosynthetic process
B0009188biological_processribonucleoside diphosphate biosynthetic process
B0015949biological_processnucleobase-containing small molecule interconversion
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016740molecular_functiontransferase activity
B0016776molecular_functionphosphotransferase activity, phosphate group as acceptor
B0019205molecular_functionnucleobase-containing compound kinase activity
B0043231cellular_componentintracellular membrane-bounded organelle
B0046033biological_processAMP metabolic process
B0046034biological_processATP metabolic process
B0046039biological_processGTP metabolic process
B0046899molecular_functionnucleoside triphosphate adenylate kinase activity
B0046940biological_processnucleoside monophosphate phosphorylation
B0050145molecular_functionnucleoside monophosphate kinase activity
B0071456biological_processcellular response to hypoxia
Functional Information from PDB Data
site_idAC1
Number of Residues29
DetailsBINDING SITE FOR RESIDUE GP5 A 225
ChainResidue
APRO14
AVAL64
AASP66
AILE69
AGLY89
AARG92
AARG122
AARG126
AASN137
APHE140
AARG170
AGLY15
AGLU198
ATHR199
AHOH238
AHOH241
AHOH258
AHOH261
AHOH266
AHOH273
AHOH279
AHOH290
ASER16
AGLY17
ALYS18
AGLY19
ATHR20
ASER36
ALEU40

site_idAC2
Number of Residues28
DetailsBINDING SITE FOR RESIDUE GP5 B 225
ChainResidue
BGLY15
BSER16
BGLY17
BLYS18
BGLY19
BTHR20
BSER36
BLEU63
BVAL64
BASP66
BILE69
BGLY89
BARG92
BARG122
BARG126
BVAL135
BTYR136
BASN137
BASP139
BPHE140
BARG170
BGLU198
BTHR199
BHOH232
BHOH243
BHOH248
BHOH250
BHOH265

Functional Information from PROSITE/UniProt
site_idPS00113
Number of Residues12
DetailsADENYLATE_KINASE Adenylate kinase signature. WLLDGFPRtlgQ
ChainResidueDetails
ATRP85-GLN96

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03170, ECO:0000269|Ref.17
ChainResidueDetails
AGLY15
BLEU62
BGLY89
BARG126
BARG170
BTHR199
ASER36
ALEU62
AGLY89
AARG126
AARG170
ATHR199
BGLY15
BSER36

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03170
ChainResidueDetails
AARG41
AGLN96
AVAL135
BARG41
BGLN96
BVAL135

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9WUR9
ChainResidueDetails
ALYS60
BLYS60

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9WUR9
ChainResidueDetails
ALYS175
BLYS175

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9WUR9
ChainResidueDetails
ALYS179
ALYS186
BLYS179
BLYS186

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PDB entries from 2024-04-24

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