2BBW
Crystal structure of human adenylate kinase 4 (AK4) in complex with diguanosine pentaphosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002082 | biological_process | regulation of oxidative phosphorylation |
| A | 0004017 | molecular_function | AMP kinase activity |
| A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006172 | biological_process | ADP biosynthetic process |
| A | 0009117 | biological_process | nucleotide metabolic process |
| A | 0009123 | biological_process | nucleoside monophosphate metabolic process |
| A | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| A | 0009188 | biological_process | ribonucleoside diphosphate biosynthetic process |
| A | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
| A | 0016776 | molecular_function | phosphotransferase activity, phosphate group as acceptor |
| A | 0019205 | molecular_function | nucleobase-containing compound kinase activity |
| A | 0036430 | molecular_function | CMP kinase activity |
| A | 0036431 | molecular_function | dCMP kinase activity |
| A | 0046033 | biological_process | AMP metabolic process |
| A | 0046034 | biological_process | ATP metabolic process |
| A | 0046039 | biological_process | GTP metabolic process |
| A | 0046899 | molecular_function | nucleoside triphosphate adenylate kinase activity |
| A | 0047506 | molecular_function | dAMP kinase activity |
| A | 0050145 | molecular_function | nucleoside monophosphate kinase activity |
| A | 0071456 | biological_process | cellular response to hypoxia |
| B | 0002082 | biological_process | regulation of oxidative phosphorylation |
| B | 0004017 | molecular_function | AMP kinase activity |
| B | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006172 | biological_process | ADP biosynthetic process |
| B | 0009117 | biological_process | nucleotide metabolic process |
| B | 0009123 | biological_process | nucleoside monophosphate metabolic process |
| B | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| B | 0009188 | biological_process | ribonucleoside diphosphate biosynthetic process |
| B | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
| B | 0016776 | molecular_function | phosphotransferase activity, phosphate group as acceptor |
| B | 0019205 | molecular_function | nucleobase-containing compound kinase activity |
| B | 0036430 | molecular_function | CMP kinase activity |
| B | 0036431 | molecular_function | dCMP kinase activity |
| B | 0046033 | biological_process | AMP metabolic process |
| B | 0046034 | biological_process | ATP metabolic process |
| B | 0046039 | biological_process | GTP metabolic process |
| B | 0046899 | molecular_function | nucleoside triphosphate adenylate kinase activity |
| B | 0047506 | molecular_function | dAMP kinase activity |
| B | 0050145 | molecular_function | nucleoside monophosphate kinase activity |
| B | 0071456 | biological_process | cellular response to hypoxia |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE GP5 A 225 |
| Chain | Residue |
| A | PRO14 |
| A | VAL64 |
| A | ASP66 |
| A | ILE69 |
| A | GLY89 |
| A | ARG92 |
| A | ARG122 |
| A | ARG126 |
| A | ASN137 |
| A | PHE140 |
| A | ARG170 |
| A | GLY15 |
| A | GLU198 |
| A | THR199 |
| A | HOH238 |
| A | HOH241 |
| A | HOH258 |
| A | HOH261 |
| A | HOH266 |
| A | HOH273 |
| A | HOH279 |
| A | HOH290 |
| A | SER16 |
| A | GLY17 |
| A | LYS18 |
| A | GLY19 |
| A | THR20 |
| A | SER36 |
| A | LEU40 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE GP5 B 225 |
| Chain | Residue |
| B | GLY15 |
| B | SER16 |
| B | GLY17 |
| B | LYS18 |
| B | GLY19 |
| B | THR20 |
| B | SER36 |
| B | LEU63 |
| B | VAL64 |
| B | ASP66 |
| B | ILE69 |
| B | GLY89 |
| B | ARG92 |
| B | ARG122 |
| B | ARG126 |
| B | VAL135 |
| B | TYR136 |
| B | ASN137 |
| B | ASP139 |
| B | PHE140 |
| B | ARG170 |
| B | GLU198 |
| B | THR199 |
| B | HOH232 |
| B | HOH243 |
| B | HOH248 |
| B | HOH250 |
| B | HOH265 |
Functional Information from PROSITE/UniProt
| site_id | PS00113 |
| Number of Residues | 12 |
| Details | ADENYLATE_KINASE Adenylate kinase signature. WLLDGFPRtlgQ |
| Chain | Residue | Details |
| A | TRP85-GLN96 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 58 |
| Details | Region: {"description":"NMP","evidences":[{"source":"HAMAP-Rule","id":"MF_03170","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19073142","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 74 |
| Details | Region: {"description":"LID","evidences":[{"source":"HAMAP-Rule","id":"MF_03170","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19073142","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03170","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2005","submissionDatabase":"PDB data bank","title":"Crystal structure of human adenylate kinase 4 (AK4) in complex with diguanosine pentaphosphate.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03170","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9WUR9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9WUR9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9WUR9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
