2B69

Crystal Structure of Human UDP-glucoronic acid decarboxylase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042732	biological_process	D-xylose metabolic process
A	0048040	molecular_function	UDP-glucuronate decarboxylase activity
A	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	BINDING SITE FOR RESIDUE NAD A 800

Chain	Residue
A	GLY11
A	THR39
A	GLY40
A	HIS59
A	ASP60
A	VAL61
A	LEU75
A	ALA76
A	SER77
A	ALA79
A	THR94
A	ALA13
A	SER117
A	THR118
A	TYR147
A	LYS151
A	ILE174
A	ASN176
A	THR177
A	ARG188
A	HOH905
A	HOH922
A	GLY14
A	HOH925
A	HOH969
A	HOH999
A	PHE15
A	VAL16
A	ASP35
A	ASN36
A	PHE37
A	PHE38

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE UDP A 900

Chain	Residue
A	PRO81
A	ARG144
A	ASN176
A	ARG188
A	VAL189
A	ASN192
A	THR204
A	VAL205
A	TYR206
A	GLN211
A	ARG213
A	ILE247
A	ASP273
A	ARG277
A	HOH934
A	HOH940
A	HOH942
A	HOH980
A	HOH1029

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE UDP A 901

Chain	Residue
A	PRO64
A	LEU65
A	TYR66
A	LEU100
A	ASN101
A	GLY104
A	LEU105
A	LYS107
A	ARG108
A	TYR161
A	HOH918
A	HOH929
A	HOH981
A	HOH985
A	HOH1183

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000269|PubMed:23656592, ECO:0000269|PubMed:25521717

Chain	Residue	Details
A	TYR147

---

site_id	SWS_FT_FI2
Number of Residues	15
Details	BINDING: BINDING => ECO:0000269|PubMed:22810237, ECO:0000269|PubMed:25521717, ECO:0007744|PDB:2B69, ECO:0007744|PDB:4LK3, ECO:0007744|PDB:4M55

Chain	Residue	Details
A	GLY14
A	VAL61
A	LEU75
A	THR94
A	LYS151
A	THR177
A	ARG188
A	PHE15
A	VAL16
A	ASP35
A	ASN36
A	PHE38
A	THR39
A	GLY40
A	ASP60

---

site_id	SWS_FT_FI3
Number of Residues	11
Details	BINDING: BINDING => ECO:0000269|PubMed:25521717, ECO:0007744|PDB:4LK3

Chain	Residue	Details
A	LEU65
A	GLN164
A	GLU165
A	TYR66
A	LYS93
A	ASN101
A	GLY104
A	LYS107
A	ARG108
A	ALA116
A	TYR161

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:25521717, ECO:0007744|PDB:4M55

Chain	Residue	Details
A	SER77

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:22810237, ECO:0007744|PDB:2B69

Chain	Residue	Details
A	TYR147

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:25521717, ECO:0007744|PDB:4LK3, ECO:0007744|PDB:4M55

Chain	Residue	Details
A	HIS183

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	THR10

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN232

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1db3

Chain	Residue	Details
A	THR118
A	LYS151
A	TYR147

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1db3

Chain	Residue	Details
A	THR118
A	GLU120
A	LYS151
A	TYR147

---