2B69

Crystal Structure of Human UDP-glucoronic acid decarboxylase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042732	biological_process	D-xylose metabolic process
A	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	BINDING SITE FOR RESIDUE NAD A 800

Chain	Residue
A	GLY11
A	THR39
A	GLY40
A	HIS59
A	ASP60
A	VAL61
A	LEU75
A	ALA76
A	SER77
A	ALA79
A	THR94
A	ALA13
A	SER117
A	THR118
A	TYR147
A	LYS151
A	ILE174
A	ASN176
A	THR177
A	ARG188
A	HOH905
A	HOH922
A	GLY14
A	HOH925
A	HOH969
A	HOH999
A	PHE15
A	VAL16
A	ASP35
A	ASN36
A	PHE37
A	PHE38

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE UDP A 900

Chain	Residue
A	PRO81
A	ARG144
A	ASN176
A	ARG188
A	VAL189
A	ASN192
A	THR204
A	VAL205
A	TYR206
A	GLN211
A	ARG213
A	ILE247
A	ASP273
A	ARG277
A	HOH934
A	HOH940
A	HOH942
A	HOH980
A	HOH1029

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE UDP A 901

Chain	Residue
A	PRO64
A	LEU65
A	TYR66
A	LEU100
A	ASN101
A	GLY104
A	LEU105
A	LYS107
A	ARG108
A	TYR161
A	HOH918
A	HOH929
A	HOH981
A	HOH985
A	HOH1183

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"23656592","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25521717","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22810237","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25521717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2B69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M55","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25521717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LK3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25521717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4M55","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22810237","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2B69","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25521717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M55","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1db3

Chain	Residue	Details
A	THR118
A	LYS151
A	TYR147

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1db3

Chain	Residue	Details
A	THR118
A	GLU120
A	LYS151
A	TYR147

---