2B56
Structural Basis for UTP Specificity of RNA Editing TUTases From Trypanosoma Brucei
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0006397 | biological_process | mRNA processing |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0031019 | cellular_component | mitochondrial mRNA editing complex |
| A | 0031123 | biological_process | RNA 3'-end processing |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050265 | molecular_function | RNA uridylyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 488 |
| Chain | Residue |
| A | ASP97 |
| A | ASP99 |
| A | UTP501 |
| A | HOH874 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE UTP A 501 |
| Chain | Residue |
| A | GLY274 |
| A | ASN277 |
| A | SER278 |
| A | LYS300 |
| A | LYS304 |
| A | SER318 |
| A | TYR319 |
| A | MG488 |
| A | HOH633 |
| A | HOH639 |
| A | HOH653 |
| A | HOH720 |
| A | HOH759 |
| A | HOH814 |
| A | HOH830 |
| A | HOH831 |
| A | HOH874 |
| A | GLY84 |
| A | SER85 |
| A | SER96 |
| A | ASP97 |
| A | ASP99 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE U5P A 601 |
| Chain | Residue |
| A | ARG144 |
| A | SER312 |
| A | GLY313 |
| A | ALA314 |
| A | MET315 |
| A | THR317 |
| A | ARG435 |
| A | HIS436 |
| A | HOH645 |
| A | HOH690 |
| A | HOH737 |
| A | HOH805 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE U5P A 602 |
| Chain | Residue |
| A | ARG282 |
| A | PRO350 |
| A | TYR352 |
| A | PRO353 |
| A | ASP354 |
| A | HOH677 |
| A | HOH682 |
| A | HOH768 |
| A | HOH774 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 59 |
| Details | Domain: {"description":"PAP-associated","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 113 |
| Details | Region: {"description":"Middle domain (MD); important for the incorporation into the RECC complex, for catalytic activity and possibly RNA binding","evidences":[{"source":"PubMed","id":"20362585","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16281058","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2B51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2B56","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16281058","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q381M1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"16281058","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fa0 |
| Chain | Residue | Details |
| A | LYS300 |
