2B51
Structural Basis for UTP Specificity of RNA Editing TUTases from Trypanosoma Brucei
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0006397 | biological_process | mRNA processing |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0031019 | cellular_component | mitochondrial mRNA editing complex |
| A | 0031123 | biological_process | RNA 3'-end processing |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050265 | molecular_function | RNA uridylyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN A 488 |
| Chain | Residue |
| A | ASP97 |
| A | ASP99 |
| A | UTP501 |
| A | HOH525 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE UTP A 501 |
| Chain | Residue |
| A | GLY274 |
| A | ASN277 |
| A | SER278 |
| A | LYS300 |
| A | LYS304 |
| A | SER318 |
| A | TYR319 |
| A | MN488 |
| A | HOH518 |
| A | HOH519 |
| A | HOH520 |
| A | HOH521 |
| A | HOH525 |
| A | HOH529 |
| A | HOH542 |
| A | HOH557 |
| A | HOH567 |
| A | HOH606 |
| A | HOH659 |
| A | HOH828 |
| A | GLY84 |
| A | SER85 |
| A | SER96 |
| A | ASP97 |
| A | ASP99 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE UTP A 502 |
| Chain | Residue |
| A | ARG144 |
| A | SER312 |
| A | GLY313 |
| A | ALA314 |
| A | MET315 |
| A | THR317 |
| A | PHE413 |
| A | ARG435 |
| A | HIS436 |
| A | HOH539 |
| A | HOH549 |
| A | HOH578 |
| A | HOH743 |
| A | HOH755 |
| A | HOH803 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE UTP A 503 |
| Chain | Residue |
| A | ARG282 |
| A | HIS283 |
| A | ASN287 |
| A | PRO350 |
| A | TYR352 |
| A | PRO353 |
| A | ASP354 |
| A | HOH666 |
| A | HOH777 |
| A | HOH780 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 59 |
| Details | Domain: {"description":"PAP-associated","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 113 |
| Details | Region: {"description":"Middle domain (MD); important for the incorporation into the RECC complex, for catalytic activity and possibly RNA binding","evidences":[{"source":"PubMed","id":"20362585","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16281058","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2B51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2B56","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16281058","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q381M1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"16281058","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fa0 |
| Chain | Residue | Details |
| A | LYS300 |
