2B4G
dihydroorotate dehydrogenase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0006106 | biological_process | fumarate metabolic process |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006222 | biological_process | UMP biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
A | 0020015 | cellular_component | glycosome |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
A | 0097014 | cellular_component | ciliary plasm |
A | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0006106 | biological_process | fumarate metabolic process |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0006222 | biological_process | UMP biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
B | 0020015 | cellular_component | glycosome |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0097014 | cellular_component | ciliary plasm |
B | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
C | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
C | 0005654 | cellular_component | nucleoplasm |
C | 0005737 | cellular_component | cytoplasm |
C | 0006106 | biological_process | fumarate metabolic process |
C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
C | 0006222 | biological_process | UMP biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
C | 0020015 | cellular_component | glycosome |
C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
C | 0097014 | cellular_component | ciliary plasm |
C | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
D | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
D | 0005654 | cellular_component | nucleoplasm |
D | 0005737 | cellular_component | cytoplasm |
D | 0006106 | biological_process | fumarate metabolic process |
D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
D | 0006222 | biological_process | UMP biosynthetic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
D | 0020015 | cellular_component | glycosome |
D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
D | 0097014 | cellular_component | ciliary plasm |
D | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE BR A 1411 |
Chain | Residue |
A | GLN139 |
A | ASN199 |
B | ILE172 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE BR A 1412 |
Chain | Residue |
A | TYR169 |
A | PHE170 |
A | HIS174 |
site_id | AC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE BR A 1414 |
Chain | Residue |
A | HOH1515 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE BR A 1415 |
Chain | Residue |
A | PRO161 |
A | HOH1500 |
site_id | AC5 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE FMN A 1400 |
Chain | Residue |
A | ALA19 |
A | ALA20 |
A | GLY21 |
A | LYS44 |
A | SER45 |
A | TYR59 |
A | ASN68 |
A | MET70 |
A | ASN128 |
A | LYS165 |
A | VAL194 |
A | ASN195 |
A | GLY222 |
A | GLY223 |
A | VAL226 |
A | CYS249 |
A | GLY250 |
A | GLY251 |
A | GLY272 |
A | THR273 |
A | ORO1399 |
A | HOH1418 |
A | HOH1438 |
A | HOH1459 |
site_id | AC6 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE ORO A 1399 |
Chain | Residue |
A | LYS44 |
A | ASN68 |
A | MET70 |
A | GLY71 |
A | LEU72 |
A | ASN128 |
A | CYS131 |
A | PRO132 |
A | ASN133 |
A | ASN195 |
A | SER196 |
A | FMN1400 |
site_id | AC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 1401 |
Chain | Residue |
A | ILE172 |
A | ARG239 |
A | ARG240 |
A | HOH1504 |
A | HOH1521 |
A | HOH1568 |
B | LYS215 |
B | PHE218 |
site_id | AC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL A 1403 |
Chain | Residue |
A | ASP277 |
D | ASP277 |
site_id | AC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE BR B 2410 |
Chain | Residue |
B | ASN296 |
D | GLU27 |
site_id | BC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE FMN B 2400 |
Chain | Residue |
B | ALA19 |
B | ALA20 |
B | GLY21 |
B | LYS44 |
B | SER45 |
B | ASN68 |
B | ASN128 |
B | LYS165 |
B | VAL194 |
B | ASN195 |
B | GLY223 |
B | VAL226 |
B | CYS249 |
B | GLY250 |
B | GLY251 |
B | GLY272 |
B | THR273 |
B | ORO2399 |
B | HOH2411 |
B | HOH2414 |
B | HOH2435 |
site_id | BC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE ORO B 2399 |
Chain | Residue |
B | LYS44 |
B | ASN68 |
B | MET70 |
B | GLY71 |
B | LEU72 |
B | ASN128 |
B | CYS131 |
B | PRO132 |
B | ASN133 |
B | ASN195 |
B | SER196 |
B | FMN2400 |
site_id | BC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE BR C 3410 |
Chain | Residue |
C | ASN296 |
site_id | BC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE BR C 3411 |
Chain | Residue |
C | LEU23 |
C | GOL3401 |
site_id | BC5 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE BR C 4410 |
Chain | Residue |
D | ILE172 |
site_id | BC6 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE FMN C 3400 |
Chain | Residue |
C | ASN68 |
C | ASN128 |
C | LYS165 |
C | VAL194 |
C | ASN195 |
C | GLY223 |
C | VAL226 |
C | CYS249 |
C | GLY250 |
C | GLY251 |
C | GLY272 |
C | THR273 |
C | ORO3399 |
C | HOH4418 |
C | HOH4421 |
C | HOH4435 |
C | ALA19 |
C | ALA20 |
C | GLY21 |
C | LYS44 |
C | SER45 |
site_id | BC7 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE ORO C 3399 |
Chain | Residue |
C | LYS44 |
C | ASN68 |
C | MET70 |
C | GLY71 |
C | LEU72 |
C | ASN128 |
C | CYS131 |
C | PRO132 |
C | ASN133 |
C | ASN195 |
C | SER196 |
C | FMN3400 |
site_id | BC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL C 3401 |
Chain | Residue |
A | HOH1556 |
A | HOH1581 |
C | TYR59 |
C | MET70 |
C | HIS276 |
C | BR3411 |
C | HOH4509 |
C | HOH4567 |
site_id | BC9 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE FMN D 4400 |
Chain | Residue |
D | ALA19 |
D | ALA20 |
D | GLY21 |
D | LYS44 |
D | SER45 |
D | TYR59 |
D | ASN68 |
D | ASN128 |
D | LYS165 |
D | VAL194 |
D | ASN195 |
D | GLY223 |
D | CYS249 |
D | GLY250 |
D | GLY251 |
D | GLY272 |
D | THR273 |
D | ORO4399 |
D | HOH4416 |
D | HOH4423 |
D | HOH4457 |
site_id | CC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE ORO D 4399 |
Chain | Residue |
D | LYS44 |
D | ASN68 |
D | MET70 |
D | GLY71 |
D | LEU72 |
D | ASN128 |
D | CYS131 |
D | PRO132 |
D | ASN133 |
D | ASN195 |
D | SER196 |
D | FMN4400 |
site_id | CC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL D 4401 |
Chain | Residue |
C | LYS215 |
C | PHE218 |
D | ILE172 |
D | ARG239 |
D | ARG240 |
D | HOH4443 |
D | HOH4512 |
D | HOH4540 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Nucleophile => ECO:0000250 |
Chain | Residue | Details |
A | CYS131 | |
B | CYS131 | |
C | CYS131 | |
D | CYS131 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18312275 |
Chain | Residue | Details |
A | ALA20 | |
B | GLY223 | |
B | CYS249 | |
B | GLY272 | |
C | ALA20 | |
C | LYS165 | |
C | VAL194 | |
C | GLY223 | |
C | CYS249 | |
C | GLY272 | |
D | ALA20 | |
A | LYS165 | |
D | LYS165 | |
D | VAL194 | |
D | GLY223 | |
D | CYS249 | |
D | GLY272 | |
A | VAL194 | |
A | GLY223 | |
A | CYS249 | |
A | GLY272 | |
B | ALA20 | |
B | LYS165 | |
B | VAL194 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | BINDING: |
Chain | Residue | Details |
A | LYS44 | |
B | ASN195 | |
C | LYS44 | |
C | ASN68 | |
C | ASN128 | |
C | ASN133 | |
C | ASN195 | |
D | LYS44 | |
D | ASN68 | |
D | ASN128 | |
D | ASN133 | |
A | ASN68 | |
D | ASN195 | |
A | ASN128 | |
A | ASN133 | |
A | ASN195 | |
B | LYS44 | |
B | ASN68 | |
B | ASN128 | |
B | ASN133 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 2dor |
Chain | Residue | Details |
A | LYS44 | |
A | CYS131 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 2dor |
Chain | Residue | Details |
B | LYS44 | |
B | CYS131 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 2dor |
Chain | Residue | Details |
C | LYS44 | |
C | CYS131 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 2dor |
Chain | Residue | Details |
D | LYS44 | |
D | CYS131 |
site_id | CSA5 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 2dor |
Chain | Residue | Details |
A | CYS131 |
site_id | CSA6 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 2dor |
Chain | Residue | Details |
B | CYS131 |
site_id | CSA7 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 2dor |
Chain | Residue | Details |
C | CYS131 |
site_id | CSA8 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 2dor |
Chain | Residue | Details |
D | CYS131 |