Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2B4G

dihydroorotate dehydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004152	molecular_function	dihydroorotate dehydrogenase activity
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0006106	biological_process	fumarate metabolic process
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006222	biological_process	UMP biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0020015	cellular_component	glycosome
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0097014	cellular_component	ciliary plasm
A	1990663	molecular_function	dihydroorotate dehydrogenase (fumarate) activity
B	0004152	molecular_function	dihydroorotate dehydrogenase activity
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006106	biological_process	fumarate metabolic process
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006222	biological_process	UMP biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
B	0020015	cellular_component	glycosome
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0097014	cellular_component	ciliary plasm
B	1990663	molecular_function	dihydroorotate dehydrogenase (fumarate) activity
C	0004152	molecular_function	dihydroorotate dehydrogenase activity
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0006106	biological_process	fumarate metabolic process
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006222	biological_process	UMP biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
C	0020015	cellular_component	glycosome
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0097014	cellular_component	ciliary plasm
C	1990663	molecular_function	dihydroorotate dehydrogenase (fumarate) activity
D	0004152	molecular_function	dihydroorotate dehydrogenase activity
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0006106	biological_process	fumarate metabolic process
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006222	biological_process	UMP biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
D	0020015	cellular_component	glycosome
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	0097014	cellular_component	ciliary plasm
D	1990663	molecular_function	dihydroorotate dehydrogenase (fumarate) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 1411

Chain	Residue
A	GLN139
A	ASN199
B	ILE172

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 1412

Chain	Residue
A	TYR169
A	PHE170
A	HIS174

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR A 1414

Chain	Residue
A	HOH1515

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR A 1415

Chain	Residue
A	PRO161
A	HOH1500

site_id	AC5
Number of Residues	24
Details	BINDING SITE FOR RESIDUE FMN A 1400

Chain	Residue
A	ALA19
A	ALA20
A	GLY21
A	LYS44
A	SER45
A	TYR59
A	ASN68
A	MET70
A	ASN128
A	LYS165
A	VAL194
A	ASN195
A	GLY222
A	GLY223
A	VAL226
A	CYS249
A	GLY250
A	GLY251
A	GLY272
A	THR273
A	ORO1399
A	HOH1418
A	HOH1438
A	HOH1459

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ORO A 1399

Chain	Residue
A	LYS44
A	ASN68
A	MET70
A	GLY71
A	LEU72
A	ASN128
A	CYS131
A	PRO132
A	ASN133
A	ASN195
A	SER196
A	FMN1400

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1401

Chain	Residue
A	ILE172
A	ARG239
A	ARG240
A	HOH1504
A	HOH1521
A	HOH1568
B	LYS215
B	PHE218

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 1403

Chain	Residue
A	ASP277
D	ASP277

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR B 2410

Chain	Residue
B	ASN296
D	GLU27

site_id	BC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FMN B 2400

Chain	Residue
B	ALA19
B	ALA20
B	GLY21
B	LYS44
B	SER45
B	ASN68
B	ASN128
B	LYS165
B	VAL194
B	ASN195
B	GLY223
B	VAL226
B	CYS249
B	GLY250
B	GLY251
B	GLY272
B	THR273
B	ORO2399
B	HOH2411
B	HOH2414
B	HOH2435

site_id	BC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ORO B 2399

Chain	Residue
B	LYS44
B	ASN68
B	MET70
B	GLY71
B	LEU72
B	ASN128
B	CYS131
B	PRO132
B	ASN133
B	ASN195
B	SER196
B	FMN2400

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR C 3410

Chain	Residue
C	ASN296

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR C 3411

Chain	Residue
C	LEU23
C	GOL3401

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR C 4410

Chain	Residue
D	ILE172

site_id	BC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FMN C 3400

Chain	Residue
C	ASN68
C	ASN128
C	LYS165
C	VAL194
C	ASN195
C	GLY223
C	VAL226
C	CYS249
C	GLY250
C	GLY251
C	GLY272
C	THR273
C	ORO3399
C	HOH4418
C	HOH4421
C	HOH4435
C	ALA19
C	ALA20
C	GLY21
C	LYS44
C	SER45

site_id	BC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ORO C 3399

Chain	Residue
C	LYS44
C	ASN68
C	MET70
C	GLY71
C	LEU72
C	ASN128
C	CYS131
C	PRO132
C	ASN133
C	ASN195
C	SER196
C	FMN3400

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 3401

Chain	Residue
A	HOH1556
A	HOH1581
C	TYR59
C	MET70
C	HIS276
C	BR3411
C	HOH4509
C	HOH4567

site_id	BC9
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FMN D 4400

Chain	Residue
D	ALA19
D	ALA20
D	GLY21
D	LYS44
D	SER45
D	TYR59
D	ASN68
D	ASN128
D	LYS165
D	VAL194
D	ASN195
D	GLY223
D	CYS249
D	GLY250
D	GLY251
D	GLY272
D	THR273
D	ORO4399
D	HOH4416
D	HOH4423
D	HOH4457

site_id	CC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ORO D 4399

Chain	Residue
D	LYS44
D	ASN68
D	MET70
D	GLY71
D	LEU72
D	ASN128
D	CYS131
D	PRO132
D	ASN133
D	ASN195
D	SER196
D	FMN4400

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 4401

Chain	Residue
C	LYS215
C	PHE218
D	ILE172
D	ARG239
D	ARG240
D	HOH4443
D	HOH4512
D	HOH4540

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000250

Chain	Residue	Details
A	CYS131
B	CYS131
C	CYS131
D	CYS131

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:18312275

Chain	Residue	Details
A	ALA20
B	GLY223
B	CYS249
B	GLY272
C	ALA20
C	LYS165
C	VAL194
C	GLY223
C	CYS249
C	GLY272
D	ALA20
A	LYS165
D	LYS165
D	VAL194
D	GLY223
D	CYS249
D	GLY272
A	VAL194
A	GLY223
A	CYS249
A	GLY272
B	ALA20
B	LYS165
B	VAL194

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING:

Chain	Residue	Details
A	LYS44
B	ASN195
C	LYS44
C	ASN68
C	ASN128
C	ASN133
C	ASN195
D	LYS44
D	ASN68
D	ASN128
D	ASN133
A	ASN68
D	ASN195
A	ASN128
A	ASN133
A	ASN195
B	LYS44
B	ASN68
B	ASN128
B	ASN133

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2dor

Chain	Residue	Details
A	LYS44
A	CYS131

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 2dor

Chain	Residue	Details
B	LYS44
B	CYS131

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 2dor

Chain	Residue	Details
C	LYS44
C	CYS131

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 2dor

Chain	Residue	Details
D	LYS44
D	CYS131

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 2dor

Chain	Residue	Details
A	CYS131

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 2dor

Chain	Residue	Details
B	CYS131

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 2dor

Chain	Residue	Details
C	CYS131

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 2dor

Chain	Residue	Details
D	CYS131

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)