2B3Z

Crystal structure of a bifunctional deaminase and reductase involved in riboflavin biosynthesis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0008270	molecular_function	zinc ion binding
A	0008703	molecular_function	5-amino-6-(5-phosphoribosylamino)uracil reductase activity
A	0008835	molecular_function	diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
A	0009231	biological_process	riboflavin biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0050661	molecular_function	NADP binding
B	0003824	molecular_function	catalytic activity
B	0008270	molecular_function	zinc ion binding
B	0008703	molecular_function	5-amino-6-(5-phosphoribosylamino)uracil reductase activity
B	0008835	molecular_function	diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
B	0009231	biological_process	riboflavin biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	0050661	molecular_function	NADP binding
C	0003824	molecular_function	catalytic activity
C	0008270	molecular_function	zinc ion binding
C	0008703	molecular_function	5-amino-6-(5-phosphoribosylamino)uracil reductase activity
C	0008835	molecular_function	diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
C	0009231	biological_process	riboflavin biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
C	0050661	molecular_function	NADP binding
D	0003824	molecular_function	catalytic activity
D	0008270	molecular_function	zinc ion binding
D	0008703	molecular_function	5-amino-6-(5-phosphoribosylamino)uracil reductase activity
D	0008835	molecular_function	diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
D	0009231	biological_process	riboflavin biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
D	0050661	molecular_function	NADP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1360

Chain	Residue
A	HIS49
A	CYS74
A	CYS83
A	HOH1362

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 1360

Chain	Residue
B	HIS49
B	GLU51
B	CYS74
B	CYS83
B	HOH1363

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 1360

Chain	Residue
C	HIS49
C	GLU51
C	CYS74
C	CYS83
C	HOH1434

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN D 1360

Chain	Residue
D	HIS49
D	CYS74
D	CYS83

---

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	39
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAEvhAIhmagahaegadiyvtle................PCshygktppCaelI

Chain	Residue	Details
A	HIS49-ILE87

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	484
Details	Domain: {"description":"CMP/dCMP-type deaminase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	572
Details	Region: {"description":"Deaminase"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	56
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---