2B3Y
Structure of a monoclinic crystal form of human cytosolic aconitase (IRP1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000900 | molecular_function | mRNA regulatory element binding translation repressor activity |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003994 | molecular_function | aconitate hydratase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006101 | biological_process | citrate metabolic process |
| A | 0006740 | biological_process | NADPH regeneration |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0010040 | biological_process | response to iron(II) ion |
| A | 0016829 | molecular_function | lyase activity |
| A | 0017148 | biological_process | negative regulation of translation |
| A | 0030350 | molecular_function | iron-responsive element binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051538 | molecular_function | 3 iron, 4 sulfur cluster binding |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0000900 | molecular_function | mRNA regulatory element binding translation repressor activity |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003994 | molecular_function | aconitate hydratase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005829 | cellular_component | cytosol |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006101 | biological_process | citrate metabolic process |
| B | 0006740 | biological_process | NADPH regeneration |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
| B | 0010040 | biological_process | response to iron(II) ion |
| B | 0016829 | molecular_function | lyase activity |
| B | 0017148 | biological_process | negative regulation of translation |
| B | 0030350 | molecular_function | iron-responsive element binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| B | 0051538 | molecular_function | 3 iron, 4 sulfur cluster binding |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 890 |
| Chain | Residue |
| A | GLN86 |
| A | PHE88 |
| A | THR89 |
| A | ARG713 |
| A | SER778 |
| A | ARG780 |
| A | HOH1045 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACT B 890 |
| Chain | Residue |
| B | ILE507 |
| B | ARG536 |
| B | ARG541 |
| B | ACT891 |
| B | SF41000 |
| B | FMT1001 |
| B | HOH1186 |
| B | HIS126 |
| B | ASP205 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT B 891 |
| Chain | Residue |
| B | GLN86 |
| B | PHE88 |
| B | THR89 |
| B | ARG713 |
| B | SER778 |
| B | ARG780 |
| B | ACT890 |
| B | FMT1001 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SF4 A 1000 |
| Chain | Residue |
| A | ILE176 |
| A | ILE177 |
| A | HIS178 |
| A | HIS207 |
| A | SER436 |
| A | CYS437 |
| A | CYS503 |
| A | CYS506 |
| A | ILE507 |
| A | ASN535 |
| A | HOH1206 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SF4 B 1000 |
| Chain | Residue |
| B | ILE176 |
| B | ILE177 |
| B | HIS178 |
| B | HIS207 |
| B | SER436 |
| B | CYS437 |
| B | CYS503 |
| B | CYS506 |
| B | ASN535 |
| B | ACT890 |
| B | HOH1186 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1001 |
| Chain | Residue |
| A | SER350 |
| A | GLN351 |
| A | HOH1194 |
| A | HOH1474 |
| A | HOH1487 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1002 |
| Chain | Residue |
| A | GLY508 |
| A | GLY540 |
| A | VAL542 |
| A | PRO544 |
| A | ASN685 |
| A | HOH1420 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT B 1001 |
| Chain | Residue |
| B | ASP205 |
| B | SER206 |
| B | ARG536 |
| B | SER778 |
| B | SER779 |
| B | ACT890 |
| B | ACT891 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1fgh |
| Chain | Residue | Details |
| A | GLU302 | |
| A | HIS207 | |
| A | HIS126 | |
| A | SER778 | |
| A | HIS178 | |
| A | ASP125 | |
| A | ASP205 |
| site_id | CSA2 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1fgh |
| Chain | Residue | Details |
| B | GLU302 | |
| B | HIS207 | |
| B | HIS126 | |
| B | SER778 | |
| B | HIS178 | |
| B | ASP125 | |
| B | ASP205 |
