2B3H
Crystal structure of Human Methionine Aminopeptidase Type I with a third cobalt in the active site
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CO A 401 |
| Chain | Residue |
| A | ASP240 |
| A | HIS303 |
| A | THR334 |
| A | GLU336 |
| A | GLU367 |
| A | CO402 |
| A | CL406 |
| A | HOH510 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CO A 402 |
| Chain | Residue |
| A | ASP240 |
| A | GLU367 |
| A | CO401 |
| A | CL406 |
| A | HOH505 |
| A | HOH510 |
| A | ASP229 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 405 |
| Chain | Residue |
| A | SER205 |
| A | ASN207 |
| A | VAL209 |
| A | SER363 |
| A | HOH508 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CL A 406 |
| Chain | Residue |
| A | HIS310 |
| A | CO401 |
| A | CO402 |
| A | CO403 |
| A | CO404 |
| A | GOL471 |
| A | HOH505 |
| A | HOH510 |
| A | HOH933 |
| A | HOH934 |
| A | HOH935 |
| A | HOH936 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CO A 403 |
| Chain | Residue |
| A | HIS212 |
| A | CO404 |
| A | CL406 |
| A | GOL471 |
| A | HOH934 |
| A | HOH935 |
| A | HOH936 |
| A | HOH937 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CO A 404 |
| Chain | Residue |
| A | HIS212 |
| A | CO403 |
| A | CL406 |
| A | GOL471 |
| A | HOH933 |
| A | HOH934 |
| A | HOH935 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL A 470 |
| Chain | Residue |
| A | THR172 |
| A | THR204 |
| A | SER205 |
| A | VAL206 |
| A | VAL209 |
| A | ILE214 |
| A | ASP216 |
| A | ARG218 |
| A | HOH502 |
| A | HOH506 |
| A | HOH564 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GOL A 471 |
| Chain | Residue |
| A | PHE198 |
| A | CYS203 |
| A | HIS212 |
| A | HIS310 |
| A | TRP353 |
| A | CO403 |
| A | CO404 |
| A | CL406 |
| A | HOH688 |
| A | HOH726 |
| A | HOH936 |
| A | HOH937 |
Functional Information from PROSITE/UniProt
| site_id | PS00680 |
| Number of Residues | 19 |
| Details | MAP_1 Methionine aminopeptidase subfamily 1 signature. YcGHGIHklfHtapnVp.HY |
| Chain | Residue | Details |
| A | TYR300-TYR318 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03174","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16724298","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16823043","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17114291","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03174","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16274222","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16724298","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16823043","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17114291","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a16 |
| Chain | Residue | Details |
| A | ASN314 | |
| A | GLU336 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a16 |
| Chain | Residue | Details |
| A | GLU336 |
