2B04
Crystal Structure of Porcine Pancreatic Phospholipase A2 in Complex with Glycochenodeoxycholate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0002446 | biological_process | neutrophil mediated immunity |
A | 0004623 | molecular_function | phospholipase A2 activity |
A | 0005102 | molecular_function | signaling receptor binding |
A | 0005509 | molecular_function | calcium ion binding |
A | 0005543 | molecular_function | phospholipid binding |
A | 0005576 | cellular_component | extracellular region |
A | 0006629 | biological_process | lipid metabolic process |
A | 0006633 | biological_process | fatty acid biosynthetic process |
A | 0006644 | biological_process | phospholipid metabolic process |
A | 0008284 | biological_process | positive regulation of cell population proliferation |
A | 0009986 | cellular_component | cell surface |
A | 0010524 | biological_process | positive regulation of calcium ion transport into cytosol |
A | 0016042 | biological_process | lipid catabolic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0019370 | biological_process | leukotriene biosynthetic process |
A | 0030593 | biological_process | neutrophil chemotaxis |
A | 0032052 | molecular_function | bile acid binding |
A | 0032652 | biological_process | regulation of interleukin-1 production |
A | 0032757 | biological_process | positive regulation of interleukin-8 production |
A | 0032869 | biological_process | cellular response to insulin stimulus |
A | 0035556 | biological_process | intracellular signal transduction |
A | 0043406 | biological_process | positive regulation of MAP kinase activity |
A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
A | 0046324 | biological_process | regulation of glucose import |
A | 0046470 | biological_process | phosphatidylcholine metabolic process |
A | 0046471 | biological_process | phosphatidylglycerol metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
A | 0048146 | biological_process | positive regulation of fibroblast proliferation |
A | 0050482 | biological_process | arachidonic acid secretion |
A | 0050778 | biological_process | positive regulation of immune response |
A | 0051092 | biological_process | positive regulation of NF-kappaB transcription factor activity |
A | 1904635 | biological_process | positive regulation of podocyte apoptotic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE CHO A 200 |
Chain | Residue |
A | PHE5 |
A | TYR111 |
A | HOH294 |
A | HOH295 |
A | HOH296 |
A | ARG6 |
A | ILE9 |
A | PHE22 |
A | ASN23 |
A | TYR25 |
A | CYS29 |
A | GLY30 |
A | PHE106 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 130 |
Chain | Residue |
A | TYR28 |
A | GLY30 |
A | GLY32 |
A | ASP49 |
A | HOH238 |
A | HOH239 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 131 |
Chain | Residue |
A | GLU71 |
A | GLU71 |
A | SER72 |
A | SER72 |
A | GLU92 |
A | GLU92 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 132 |
Chain | Residue |
A | LYS62 |
A | LYS62 |
A | CL135 |
A | CL135 |
A | HOH214 |
A | HOH214 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL A 135 |
Chain | Residue |
A | LYS62 |
A | LYS62 |
A | CA132 |
A | CA132 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:6876174 |
Chain | Residue | Details |
A | HIS48 | |
A | ASP99 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00593 |
Chain | Residue | Details |
A | TYR28 | |
A | GLY30 | |
A | GLY32 | |
A | ASP49 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | LIPID: N6-palmitoyl lysine => ECO:0000269|PubMed:2498336 |
Chain | Residue | Details |
A | LYS56 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 8 |
Details | M-CSA 83 |
Chain | Residue | Details |
A | TYR28 | metal ligand |
A | GLY30 | metal ligand |
A | GLY32 | metal ligand |
A | HIS48 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | ASP49 | metal ligand |
A | TYR52 | electrostatic stabiliser, hydrogen bond donor |
A | TYR73 | electrostatic stabiliser, hydrogen bond donor |
A | ASP99 | electrostatic stabiliser, hydrogen bond acceptor |