2AZ1
Structure of a halophilic nucleoside diphosphate kinase from Halobacterium salinarum
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006183 | biological_process | GTP biosynthetic process |
| A | 0006228 | biological_process | UTP biosynthetic process |
| A | 0006241 | biological_process | CTP biosynthetic process |
| A | 0009117 | biological_process | nucleotide metabolic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006183 | biological_process | GTP biosynthetic process |
| B | 0006228 | biological_process | UTP biosynthetic process |
| B | 0006241 | biological_process | CTP biosynthetic process |
| B | 0009117 | biological_process | nucleotide metabolic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006183 | biological_process | GTP biosynthetic process |
| C | 0006228 | biological_process | UTP biosynthetic process |
| C | 0006241 | biological_process | CTP biosynthetic process |
| C | 0009117 | biological_process | nucleotide metabolic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006183 | biological_process | GTP biosynthetic process |
| D | 0006228 | biological_process | UTP biosynthetic process |
| D | 0006241 | biological_process | CTP biosynthetic process |
| D | 0009117 | biological_process | nucleotide metabolic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006183 | biological_process | GTP biosynthetic process |
| E | 0006228 | biological_process | UTP biosynthetic process |
| E | 0006241 | biological_process | CTP biosynthetic process |
| E | 0009117 | biological_process | nucleotide metabolic process |
| E | 0016301 | molecular_function | kinase activity |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006183 | biological_process | GTP biosynthetic process |
| F | 0006228 | biological_process | UTP biosynthetic process |
| F | 0006241 | biological_process | CTP biosynthetic process |
| F | 0009117 | biological_process | nucleotide metabolic process |
| F | 0016301 | molecular_function | kinase activity |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 201 |
| Chain | Residue |
| C | ALA134 |
| C | PHE137 |
| C | ASP138 |
| D | GLU47 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA D 202 |
| Chain | Residue |
| C | GLU47 |
| D | ALA134 |
| D | PHE137 |
| D | ASP138 |
| D | HOH225 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 203 |
| Chain | Residue |
| A | HIS52 |
| A | GLU55 |
| A | ARG131 |
| A | HOH222 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 204 |
| Chain | Residue |
| C | ASP138 |
| D | ASP45 |
| D | GLU47 |
| D | HOH213 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA D 205 |
| Chain | Residue |
| C | ASP45 |
| D | ASP138 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Pros-phosphohistidine intermediate => ECO:0000255|HAMAP-Rule:MF_00451 |
| Chain | Residue | Details |
| A | HIS119 | |
| B | HIS119 | |
| C | HIS119 | |
| D | HIS119 | |
| E | HIS119 | |
| F | HIS119 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00451, ECO:0000305|PubMed:16293253 |
| Chain | Residue | Details |
| A | LYS13 | |
| B | THR95 | |
| B | ARG106 | |
| B | ASN116 | |
| C | LYS13 | |
| C | PHE61 | |
| C | ARG89 | |
| C | THR95 | |
| C | ARG106 | |
| C | ASN116 | |
| D | LYS13 | |
| A | PHE61 | |
| D | PHE61 | |
| D | ARG89 | |
| D | THR95 | |
| D | ARG106 | |
| D | ASN116 | |
| E | LYS13 | |
| E | PHE61 | |
| E | ARG89 | |
| E | THR95 | |
| E | ARG106 | |
| A | ARG89 | |
| E | ASN116 | |
| F | LYS13 | |
| F | PHE61 | |
| F | ARG89 | |
| F | THR95 | |
| F | ARG106 | |
| F | ASN116 | |
| A | THR95 | |
| A | ARG106 | |
| A | ASN116 | |
| B | LYS13 | |
| B | PHE61 | |
| B | ARG89 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| A | LYS13 | |
| A | ASN116 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| D | LYS13 | |
| D | TYR53 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| E | LYS13 | |
| E | TYR53 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| F | LYS13 | |
| F | TYR53 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| B | LYS13 | |
| B | ASN116 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| C | LYS13 | |
| C | ASN116 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| D | LYS13 | |
| D | ASN116 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| E | LYS13 | |
| E | ASN116 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| F | LYS13 | |
| F | ASN116 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| A | LYS13 | |
| A | TYR53 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| B | LYS13 | |
| B | TYR53 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| C | LYS13 | |
| C | TYR53 |
