2AWD
Crystal structure of LacC from Enterococcus faecalis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0005988 | biological_process | lactose metabolic process |
| A | 0008443 | molecular_function | phosphofructokinase activity |
| A | 0009024 | molecular_function | tagatose-6-phosphate kinase activity |
| A | 0016052 | biological_process | carbohydrate catabolic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| A | 0044281 | biological_process | small molecule metabolic process |
| A | 0046835 | biological_process | carbohydrate phosphorylation |
| A | 2001059 | biological_process | D-tagatose 6-phosphate catabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0005988 | biological_process | lactose metabolic process |
| B | 0008443 | molecular_function | phosphofructokinase activity |
| B | 0009024 | molecular_function | tagatose-6-phosphate kinase activity |
| B | 0016052 | biological_process | carbohydrate catabolic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| B | 0044281 | biological_process | small molecule metabolic process |
| B | 0046835 | biological_process | carbohydrate phosphorylation |
| B | 2001059 | biological_process | D-tagatose 6-phosphate catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR A 401 |
| Chain | Residue |
| A | LYS38 |
| A | ARG88 |
| A | SER136 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR B 402 |
| Chain | Residue |
| B | LYS38 |
| B | ARG88 |
| B | SER136 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR A 403 |
| Chain | Residue |
| A | ALA312 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR A 404 |
| Chain | Residue |
| A | ARG44 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR B 405 |
| Chain | Residue |
| B | SER168 |
| B | LEU169 |
| B | THR164 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR B 406 |
| Chain | Residue |
| B | PRO212 |
| B | MSE213 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR B 407 |
| Chain | Residue |
| B | ALA105 |
| B | GLY106 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR A 408 |
| Chain | Residue |
| A | ALA105 |
| A | GLY106 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR B 409 |
| Chain | Residue |
| B | ARG44 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR A 410 |
| Chain | Residue |
| A | GLN174 |
| A | HOH584 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR A 411 |
| Chain | Residue |
| A | ALA312 |
| A | LYS313 |
| B | GLN307 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR A 412 |
| Chain | Residue |
| A | HOH562 |
Functional Information from PROSITE/UniProt
| site_id | PS00583 |
| Number of Residues | 25 |
| Details | PFKB_KINASES_1 pfkB family of carbohydrate kinases signature 1. GGkGlNVTrvIhDLGgdviatgvlG |
| Chain | Residue | Details |
| A | GLY36-GLY60 |
| site_id | PS00584 |
| Number of Residues | 14 |
| Details | PFKB_KINASES_2 pfkB family of carbohydrate kinases signature 2. NPvGSGDatiAGLA |
| Chain | Residue | Details |
| A | ASN249-ALA262 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1tz3 |
| Chain | Residue | Details |
| A | GLY254 | |
| A | ASP255 | |
| A | SER253 | |
| A | GLY252 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1tz3 |
| Chain | Residue | Details |
| B | GLY254 | |
| B | ASP255 | |
| B | SER253 | |
| B | GLY252 |
