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2ATX

Crystal Structure of the TC10 GppNHp complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005522molecular_functionprofilin binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0006897biological_processendocytosis
A0007015biological_processactin filament organization
A0007163biological_processestablishment or maintenance of cell polarity
A0007165biological_processsignal transduction
A0007264biological_processsmall GTPase-mediated signal transduction
A0008286biological_processinsulin receptor signaling pathway
A0008360biological_processregulation of cell shape
A0019901molecular_functionprotein kinase binding
A0030660cellular_componentGolgi-associated vesicle membrane
A0030866biological_processcortical actin cytoskeleton organization
A0032427molecular_functionGBD domain binding
A0032869biological_processcellular response to insulin stimulus
A0032956biological_processregulation of actin cytoskeleton organization
A0045121cellular_componentmembrane raft
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046039biological_processGTP metabolic process
A0046326biological_processpositive regulation of D-glucose import
A0051491biological_processpositive regulation of filopodium assembly
A0070062cellular_componentextracellular exosome
A1903077biological_processnegative regulation of protein localization to plasma membrane
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005522molecular_functionprofilin binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005884cellular_componentactin filament
B0005886cellular_componentplasma membrane
B0006897biological_processendocytosis
B0007015biological_processactin filament organization
B0007163biological_processestablishment or maintenance of cell polarity
B0007165biological_processsignal transduction
B0007264biological_processsmall GTPase-mediated signal transduction
B0008286biological_processinsulin receptor signaling pathway
B0008360biological_processregulation of cell shape
B0019901molecular_functionprotein kinase binding
B0030660cellular_componentGolgi-associated vesicle membrane
B0030866biological_processcortical actin cytoskeleton organization
B0032427molecular_functionGBD domain binding
B0032869biological_processcellular response to insulin stimulus
B0032956biological_processregulation of actin cytoskeleton organization
B0045121cellular_componentmembrane raft
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046039biological_processGTP metabolic process
B0046326biological_processpositive regulation of D-glucose import
B0051491biological_processpositive regulation of filopodium assembly
B0070062cellular_componentextracellular exosome
B1903077biological_processnegative regulation of protein localization to plasma membrane
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 201
ChainResidue
ATHR31
ATHR49
AASP71
AGNP200
AHOH202
AHOH203

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 1201
ChainResidue
BHOH1202
BHOH1203
BTHR31
BTHR49
BGNP1200

site_idAC3
Number of Residues20
DetailsBINDING SITE FOR RESIDUE GNP A 200
ChainResidue
AASP25
AGLY26
AALA27
AVAL28
AGLY29
ALYS30
ATHR31
ACYS32
APHE42
ATHR49
AGLY74
AGLN130
AASP132
ALEU133
ASER172
AALA173
ALEU174
AMG201
AHOH202
AHOH206

site_idAC4
Number of Residues19
DetailsBINDING SITE FOR RESIDUE GNP B 1200
ChainResidue
BGLY26
BALA27
BVAL28
BGLY29
BLYS30
BTHR31
BCYS32
BPHE42
BTHR49
BGLY74
BGLN130
BASP132
BLEU133
BSER172
BALA173
BLEU174
BMG1201
BHOH1202
BHOH1203

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLY24
AASP71
ATHR129
BGLY24
BASP71
BTHR129

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN75

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BGLN75

225946

PDB entries from 2024-10-09

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