2AT3

1.00 A Crystal Structure Of L123V/L133V Mutant of Nitrophorin 4 From Rhodnius Prolixus Complexed With Imidazole at pH 5.6

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0005576	cellular_component	extracellular region
X	0016491	molecular_function	oxidoreductase activity
X	0042311	biological_process	vasodilation
X	0046872	molecular_function	metal ion binding
X	0051381	molecular_function	histamine binding
X	0070026	molecular_function	nitric oxide binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM X 185

Chain	Residue
X	VAL36
X	TYR105
X	ILE119
X	VAL123
X	LYS125
X	LYS128
X	LEU130
X	IMD186
X	HOH267
X	PRO37
X	TYR40
X	LEU44
X	LEU57
X	HIS59
X	ASP70
X	PHE86
X	LYS88

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IMD X 186

Chain	Residue
X	VAL123
X	LEU130
X	VAL133
X	HEM185
X	HOH212

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: proximal binding residue => ECO:0000269|PubMed:10876239, ECO:0000269|PubMed:11560480, ECO:0000269|PubMed:14673714, ECO:0000269|PubMed:16171383, ECO:0000269|PubMed:20524697, ECO:0000269|PubMed:22334402, ECO:0000269|PubMed:22976968, ECO:0000269|PubMed:23474537, ECO:0000269|PubMed:9782054

Chain	Residue	Details
X	HIS59

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