2ASS

Crystal structure of the Skp1-Skp2-Cks1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000209	biological_process	protein polyubiquitination
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006338	biological_process	chromatin remodeling
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006513	biological_process	protein monoubiquitination
A	0006915	biological_process	apoptotic process
A	0008013	molecular_function	beta-catenin binding
A	0016567	biological_process	protein ubiquitination
A	0019005	cellular_component	SCF ubiquitin ligase complex
A	0019904	molecular_function	protein domain specific binding
A	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
A	0031519	cellular_component	PcG protein complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051457	biological_process	maintenance of protein location in nucleus
A	0061564	biological_process	axon development
A	0070936	biological_process	protein K48-linked ubiquitination
A	0097602	molecular_function	cullin family protein binding
A	0140677	molecular_function	molecular function activator activity
A	0160072	molecular_function	ubiquitin ligase complex scaffold activity
A	1904037	biological_process	positive regulation of epithelial cell apoptotic process
A	1990444	molecular_function	F-box domain binding
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
A	1990757	molecular_function	ubiquitin ligase activator activity
C	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 B 3

Chain	Residue
B	HOH67
B	HIS2199
B	SER2203
B	THR2225
C	PRO3062

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 C 4

Chain	Residue
C	SER3051
C	TRP3054
C	HOH72
C	LYS3011
C	ARG3020
C	GLN3050

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 B 5

Chain	Residue
B	ASN2190
B	GLU2214
B	GLY2215
C	LEU3037
C	MET3038
C	SER3039
C	HIS3056

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BEN B 1

Chain	Residue
B	HOH22
B	HOH38
B	ALA2227
B	SER2254
C	HIS3060
C	GLU3063

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BEN C 2

Chain	Residue
B	PHE2169
B	VAL2192
C	TYR3057
C	MET3058

---

Functional Information from PROSITE/UniProt

site_id	PS00944
Number of Residues	19
Details	CKS_1 Cyclin-dependent kinases regulatory subunits signature 1. YSdKYdDEeFEYRHVmLPK

Chain	Residue	Details
C	TYR3008-LYS3026

---

site_id	PS00945
Number of Residues	11
Details	CKS_2 Cyclin-dependent kinases regulatory subunits signature 2. HePEpHILLFR

Chain	Residue	Details
C	HIS3060-ARG3070

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	25
Details	Repeat: {"description":"LRR 1","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	27
Details	Repeat: {"description":"LRR 2","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Repeat: {"description":"LRR 3","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	22
Details	Repeat: {"description":"LRR 4","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	26
Details	Repeat: {"description":"LRR 5","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	22
Details	Repeat: {"description":"LRR 6","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	Repeat: {"description":"LRR 7","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	22
Details	Repeat: {"description":"LRR 8","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	19
Details	Repeat: {"description":"LRR 9","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	21
Details	Repeat: {"description":"LRR 10","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---