2ASS
Crystal structure of the Skp1-Skp2-Cks1 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000082 | biological_process | G1/S transition of mitotic cell cycle |
| A | 0000209 | biological_process | protein polyubiquitination |
| A | 0000785 | cellular_component | chromatin |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005813 | cellular_component | centrosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0007346 | biological_process | regulation of mitotic cell cycle |
| A | 0008013 | molecular_function | beta-catenin binding |
| A | 0010564 | biological_process | regulation of cell cycle process |
| A | 0010824 | biological_process | regulation of centrosome duplication |
| A | 0014033 | biological_process | neural crest cell differentiation |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0019005 | cellular_component | SCF ubiquitin ligase complex |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030510 | biological_process | regulation of BMP signaling pathway |
| A | 0031146 | biological_process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| A | 0031467 | cellular_component | Cul7-RING ubiquitin ligase complex |
| A | 0031507 | biological_process | heterochromatin formation |
| A | 0031519 | cellular_component | PcG protein complex |
| A | 0032006 | biological_process | regulation of TOR signaling |
| A | 0042752 | biological_process | regulation of circadian rhythm |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0050727 | biological_process | regulation of inflammatory response |
| A | 0051124 | biological_process | synaptic assembly at neuromuscular junction |
| A | 0051298 | biological_process | centrosome duplication |
| A | 0051457 | biological_process | maintenance of protein location in nucleus |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0060173 | biological_process | limb development |
| A | 0060271 | biological_process | cilium assembly |
| A | 0070936 | biological_process | protein K48-linked ubiquitination |
| A | 0097602 | molecular_function | cullin family protein binding |
| A | 0140677 | molecular_function | molecular function activator activity |
| A | 0160072 | molecular_function | ubiquitin ligase complex scaffold activity |
| A | 1901524 | biological_process | regulation of mitophagy |
| A | 1904415 | biological_process | regulation of xenophagy |
| A | 1990444 | molecular_function | F-box domain binding |
| A | 1990756 | molecular_function | ubiquitin-like ligase-substrate adaptor activity |
| A | 1990757 | molecular_function | ubiquitin ligase activator activity |
| A | 2000001 | biological_process | regulation of DNA damage checkpoint |
| C | 0016538 | molecular_function | cyclin-dependent protein serine/threonine kinase regulator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 3 |
| Chain | Residue |
| B | HOH67 |
| B | HIS2199 |
| B | SER2203 |
| B | THR2225 |
| C | PRO3062 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 C 4 |
| Chain | Residue |
| C | SER3051 |
| C | TRP3054 |
| C | HOH72 |
| C | LYS3011 |
| C | ARG3020 |
| C | GLN3050 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 5 |
| Chain | Residue |
| B | ASN2190 |
| B | GLU2214 |
| B | GLY2215 |
| C | LEU3037 |
| C | MET3038 |
| C | SER3039 |
| C | HIS3056 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BEN B 1 |
| Chain | Residue |
| B | HOH22 |
| B | HOH38 |
| B | ALA2227 |
| B | SER2254 |
| C | HIS3060 |
| C | GLU3063 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BEN C 2 |
| Chain | Residue |
| B | PHE2169 |
| B | VAL2192 |
| C | TYR3057 |
| C | MET3058 |
Functional Information from PROSITE/UniProt
| site_id | PS00944 |
| Number of Residues | 19 |
| Details | CKS_1 Cyclin-dependent kinases regulatory subunits signature 1. YSdKYdDEeFEYRHVmLPK |
| Chain | Residue | Details |
| C | TYR3008-LYS3026 |
| site_id | PS00945 |
| Number of Residues | 11 |
| Details | CKS_2 Cyclin-dependent kinases regulatory subunits signature 2. HePEpHILLFR |
| Chain | Residue | Details |
| C | HIS3060-ARG3070 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 25 |
| Details | Repeat: {"description":"LRR 1","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 27 |
| Details | Repeat: {"description":"LRR 2","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | Repeat: {"description":"LRR 3","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | Repeat: {"description":"LRR 4","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 26 |
| Details | Repeat: {"description":"LRR 5","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | Repeat: {"description":"LRR 6","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 7","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 22 |
| Details | Repeat: {"description":"LRR 8","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"LRR 9","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 10","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
