2AQ9

Structure of E. coli LpxA with a bound peptide that is competitive with acyl-ACP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0008610	biological_process	lipid biosynthetic process
A	0008780	molecular_function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
A	0009103	biological_process	lipopolysaccharide biosynthetic process
A	0009245	biological_process	lipid A biosynthetic process
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0042802	molecular_function	identical protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 A 301

Chain	Residue
A	ARG100
A	ARG216
A	LYS220
A	PO4302
A	HOH453
A	HOH540
A	HOH542
A	HOH613
A	HOH689

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 302

Chain	Residue
A	PRO34
A	ASN51
A	GLY52
A	PO4301
A	HOH431
A	HOH488
A	HOH517
A	HOH518
A	HOH605
A	HOH660

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 303

Chain	Residue
A	LYS76
A	GLN104
A	LYS203
A	HOH536
A	HOH572
A	HOH598
X	TRP4
X	ARG15

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 304

Chain	Residue
A	LEU75
A	ASP114
A	ARG132
A	CYS133

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 401

Chain	Residue
A	ILE13
A	VAL14
A	GLU16

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 402

Chain	Residue
A	ILE56
A	ILE86
A	DMS405

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 403

Chain	Residue
A	GLY17
A	PRO34
A	HIS35
A	VAL36
A	GLU37

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 404

Chain	Residue
A	ASN23
A	HIS25
A	GLY41
A	ASN217
A	LEU239
A	TYR243
A	DMS408

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS A 405

Chain	Residue
A	ASP88
A	DMS402

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS A 406

Chain	Residue
A	ASP148
A	ARG255

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS A 407

Chain	Residue
A	HIS25
A	HOH549

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 408

Chain	Residue
A	GLY41
A	ASP59
A	ASN60
A	GLU210
A	THR213
A	TYR243
A	DMS404

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 409

Chain	Residue
A	HIS144
A	SER146
A	PHE162
A	THR257
A	DMS412

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS A 410

Chain	Residue
A	PHE7
A	VAL8

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS A 411

Chain	Residue
A	ASP148
A	ASP149

---

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 412

Chain	Residue
A	ASP126
A	THR128
A	VAL145
A	SER146
A	DMS409
A	HOH450
A	HOH703

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 413

Chain	Residue
A	LYS4
A	ALA6
A	GLU238
A	HOH530

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 414

Chain	Residue
A	MET1
A	ASP3
A	ILE20

---

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS A 415

Chain	Residue
A	ASP3
A	LYS4

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 416

Chain	Residue
A	GLU15
A	PRO28
A	HOH491
A	HOH549

---

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 417

Chain	Residue
A	ASN131
A	ARG132
A	PHE150
A	HOH625

---

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS A 418

Chain	Residue
A	PRO194
A	TYR219

---

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 419

Chain	Residue
A	HOH445
A	ARG205
A	GLU245

---

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 420

Chain	Residue
A	HIS25
A	VAL43
A	LYS45
A	HOH695

---

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 421

Chain	Residue
A	GLN73
A	ARG91
A	ARG93
A	LEU116
A	HOH524

---

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 422

Chain	Residue
A	ALA78
A	PHE207
A	ARG209

---

site_id	CC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 X 305

Chain	Residue
A	GLN73
A	ASP74
A	LEU75
A	LYS76
A	GLN161
X	LEU6
X	PRO8
X	HOH28

---

Functional Information from PROSITE/UniProt

site_id	PS00101
Number of Residues	29
Details	HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IGanAhIgpfCiVGphVeIGegTvLkshV

Chain	Residue	Details
A	ILE20-VAL48
A	ILE153-VAL181

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
A	HIS125

---

site_id	MCSA1
Number of Residues	3
Details	M-CSA 69

Chain	Residue	Details
A	HIS125	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	ASP126	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	GLY143	electrostatic stabiliser, hydrogen bond donor

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