2APC

Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with UDP-GlcNAc phosphonate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008375	molecular_function	acetylglucosaminyltransferase activity
A	0009101	biological_process	glycoprotein biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 448

Chain	Residue
A	ASP213
A	UDM449
A	HOH492
A	HOH539
A	HOH564

---

site_id	AC2
Number of Residues	35
Details	BINDING SITE FOR RESIDUE UDM A 449

Chain	Residue
A	ASP144
A	CYS145
A	TYR184
A	LYS186
A	ILE187
A	HIS190
A	GLU211
A	ASP212
A	ASP213
A	LEU269
A	TRP290
A	ASP291
A	GLY320
A	VAL321
A	SER322
A	LEU331
A	MN448
A	GOL450
A	HOH459
A	HOH482
A	HOH494
A	HOH525
A	HOH564
A	HOH644
A	HOH645
A	HOH646
A	HOH647
A	HOH648
A	HOH650
A	HOH706
A	HOH707
A	ILE113
A	ALA114
A	CYS115
A	ARG117

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 450

Chain	Residue
A	PHE289
A	ASP291
A	ASP292
A	UDM449
A	HOH650
A	HOH728

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 451

Chain	Residue
A	ARG131
A	ILE139
A	ILE140
A	SER159
A	ALA160
A	VAL161
A	THR162

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 452

Chain	Residue
A	TYR390
A	GLY412
A	PRO435
A	TRP439
A	GLY441
A	TYR442
A	ASP443
A	TRP446

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 453

Chain	Residue
A	GLU149
A	ARG189
A	ARG192
A	HOH499
A	HOH552

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 454

Chain	Residue
A	ASP116
A	PRO167
A	HOH525
A	HOH541
A	HOH580
A	HOH707

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 455

Chain	Residue
A	PRO235
A	LEU237
A	LEU274
A	ARG303
A	HOH486
A	HOH510
A	HOH710

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11032794","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16769084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AM5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2APC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11032794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FOA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11032794","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16769084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AM5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1foa

Chain	Residue	Details
A	ASP291

---

site_id	MCSA1
Number of Residues	2
Details	M-CSA 770

Chain	Residue	Details
A	ASP213	metal ligand
A	ASP291	activator, proton acceptor, proton donor

---