2AOX

Histamine Methyltransferase (Primary Variant T105) Complexed with the Acetylcholinesterase Inhibitor and Altzheimer's Disease Drug Tacrine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001692	biological_process	histamine metabolic process
A	0001695	biological_process	histamine catabolic process
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006548	biological_process	L-histidine catabolic process
A	0007585	biological_process	respiratory gaseous exchange by respiratory system
A	0008168	molecular_function	methyltransferase activity
A	0008170	molecular_function	N-methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation
A	0046539	molecular_function	histamine N-methyltransferase activity
A	0070062	cellular_component	extracellular exosome
B	0001692	biological_process	histamine metabolic process
B	0001695	biological_process	histamine catabolic process
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006548	biological_process	L-histidine catabolic process
B	0007585	biological_process	respiratory gaseous exchange by respiratory system
B	0008168	molecular_function	methyltransferase activity
B	0008170	molecular_function	N-methyltransferase activity
B	0016740	molecular_function	transferase activity
B	0032259	biological_process	methylation
B	0046539	molecular_function	histamine N-methyltransferase activity
B	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE THA A 400

Chain	Residue
A	PHE19
A	PHE22
A	GLU28
A	GLN143
A	TYR147
A	TRP183

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE THA B 401

Chain	Residue
B	GLN143
B	TYR147
B	TRP183
B	PHE19
B	PHE22
B	GLU28

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Binding site: {}

Chain

Residue

Details

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