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2AOV

Histamine Methyltransferase Complexed with the Antifolate Drug Metoprine

Functional Information from GO Data
ChainGOidnamespacecontents
A0001692biological_processhistamine metabolic process
A0001695biological_processhistamine catabolic process
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0006548biological_processL-histidine catabolic process
A0007585biological_processrespiratory gaseous exchange by respiratory system
A0008168molecular_functionmethyltransferase activity
A0008170molecular_functionN-methyltransferase activity
A0032259biological_processmethylation
A0046539molecular_functionhistamine N-methyltransferase activity
A0070062cellular_componentextracellular exosome
B0001692biological_processhistamine metabolic process
B0001695biological_processhistamine catabolic process
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0006548biological_processL-histidine catabolic process
B0007585biological_processrespiratory gaseous exchange by respiratory system
B0008168molecular_functionmethyltransferase activity
B0008170molecular_functionN-methyltransferase activity
B0032259biological_processmethylation
B0046539molecular_functionhistamine N-methyltransferase activity
B0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE 4DI B 300
ChainResidue
BGLY60
BGLU89
BTHR119
BILE142
BMET144

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE 4DI A 301
ChainResidue
ATYR15
AMET144

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE C2M B 400
ChainResidue
BGLN143
BTYR146
BTYR147
BTRP179
BTRP183
BGLN197
BTYR198
BTYR15
BGLU28

site_idAC4
Number of Residues11
DetailsBINDING SITE FOR RESIDUE C2M A 401
ChainResidue
ATYR15
AGLU28
AGLN143
ATYR146
ATYR147
AVAL173
ATRP179
ATRP183
AGLN197
ATYR198
AHOH423

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBINDING:
ChainResidueDetails
AGLU28
BGLU89
BGLN94
BSER120
BILE142
BASN283
AGLY60
AGLU89
AGLN94
ASER120
AILE142
AASN283
BGLU28
BGLY60

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PDB entries from 2024-07-17

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