2AMG

STRUCTURE OF HYDROLASE (GLYCOSIDASE)

Replaces:  1AMG

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004556	molecular_function	alpha-amylase activity
A	0005975	biological_process	carbohydrate metabolic process
A	0043169	molecular_function	cation binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 451

Chain	Residue
A	ASN116
A	ASP151
A	ASP154
A	ASP162
A	GLY197
A	HOH553

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 452

Chain	Residue
A	ASP16
A	GLU17
A	ASP1
A	GLN2
A	HIS13

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"10556241","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"10556241","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9281429","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10556241","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9126844","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9281429","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10556241","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10556241","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9281429","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P0C1B3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"10556241","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	a catalytic site defined by CSA, PubMed 9126844, 9281429, 10556241, 11272837

Chain	Residue	Details
A	ASP294
A	ASP193
A	GLU219

---