2AM5

Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with UDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006486	biological_process	obsolete protein glycosylation
A	0008375	molecular_function	acetylglucosaminyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 448

Chain	Residue
A	ASP213
A	UDP449
A	HOH489
A	HOH528
A	HOH545

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site_id	AC2
Number of Residues	24
Details	BINDING SITE FOR RESIDUE UDP A 449

Chain	Residue
A	ASP144
A	CYS145
A	LYS186
A	ILE187
A	HIS190
A	GLU211
A	ASP212
A	ASP213
A	GLY320
A	VAL321
A	SER322
A	MN448
A	GOL454
A	HOH490
A	HOH514
A	HOH545
A	HOH657
A	HOH690
A	HOH703
A	HOH715
A	ILE113
A	ALA114
A	CYS115
A	ARG117

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 450

Chain	Residue
A	ARG131
A	PRO138
A	ILE139
A	SER159
A	ALA160
A	THR162

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 451

Chain	Residue
A	TYR390
A	GLY412
A	GLY420
A	TRP439
A	GLY441
A	TYR442
A	ASP443
A	TRP446

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 452

Chain	Residue
A	ASP116
A	PRO167
A	VAL321
A	HOH514
A	HOH594
A	HOH607
A	HOH690

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 453

Chain	Residue
A	PRO235
A	LEU237
A	LEU274
A	ARG303
A	HOH484
A	HOH504

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 454

Chain	Residue
A	TYR184
A	GLU211
A	UDP449
A	HOH489
A	HOH596
A	HOH715

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11032794","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16769084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AM5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2APC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11032794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FOA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11032794","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16769084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AM5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1foa

Chain	Residue	Details
A	ASP291

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site_id	MCSA1
Number of Residues	2
Details	M-CSA 770

Chain	Residue	Details
A	ASP213	metal ligand
A	ASP291	activator, proton acceptor, proton donor

---