2ALR

ALDEHYDE REDUCTASE

Replaces:  1ALR
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Functional Information from GO Data

ChainGOidnamespacecontents
A0016324cellular_componentapical plasma membrane
A0005829cellular_componentcytosol
A0070062cellular_componentextracellular exosome
A0005615cellular_componentextracellular space
A0045202cellular_componentsynapse
A0008106molecular_functionalcohol dehydrogenase (NADP+) activity
A0004032molecular_functionalditol:NADP+ 1-oxidoreductase activity
A0004033molecular_functionaldo-keto reductase (NADP) activity
A0009055molecular_functionelectron transfer activity
A0047941molecular_functionglucuronolactone reductase activity
A0047939molecular_functionL-glucuronate reductase activity
A0016491molecular_functionoxidoreductase activity
A0046185biological_processaldehyde catabolic process
A0006081biological_processcellular aldehyde metabolic process
A0110095biological_processcellular detoxification of aldehyde
A0042840biological_processD-glucuronate catabolic process
A0006006biological_processglucose metabolic process
A0019640biological_processglucuronate catabolic process to xylulose 5-phosphate
A1901687biological_processglutathione derivative biosynthetic process
A0019853biological_processL-ascorbic acid biosynthetic process
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS0006218Aldo/keto reductase family signature 2. [LIVMFY]-x(8)-{L}-[KREQ]-{K}-[LIVM]-G-[LIVM]-[SC]-N-[FY]
ChainResidueDetails
ALEU146-PHE163

PS0006316Aldo/keto reductase family putative active site signature. [LIVM]-[PAIV]-[KR]-[ST]-{EPQG}-{RFI}-x(2)-R-{SVAF}-x-[GSTAEQK]-[NSL]-x
ChainResidueDetails
AILE260-VAL275

PS0079818Aldo/keto reductase family signature 1. G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGCL]-[AS]-x(5)-[EQ]-x(2)-[LIVMCA]-[GS]
ChainResidueDetails
AGLY39-GLY56

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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI11Proton donor.
ChainResidueDetails
ATYR49

SWS_FT_FI21Substrate.
ChainResidueDetails
AHIS112

SWS_FT_FI31Lowers pKa of active site Tyr.
ChainResidueDetails
ALYS79

SWS_FT_FI463NADP (By similarity).
ChainResidueDetails
ASER210-ASN272

CATRES12a catalytic site defined by CATRES, Medline 92320300, 94250245, 96022988, 97439701, 98284006
ChainResidueDetails
ALYS79activates water, cofactor or residue. stabilises Y49
ATYR49acid/base. donates proton to substrate

CSA12a catalytic site defined by CSA, PubMed 1621098, 8192670, 7552731, 9307009, 9618487
ChainResidueDetails
ATYR49
ALYS79

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Catalytic Information from CSA

site_idNumber of ResiduesDetails
CSA12a catalytic site defined by CSA, PubMed 1621098, 8192670, 7552731, 9307009, 9618487
ChainResidueDetails
ATYR49
ALYS79