Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2AJQ

Structure of replicative DNA polymerase provides insigts into the mechanisms for processivity, frameshifting and editing

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003824molecular_functioncatalytic activity
A0003887molecular_functionDNA-directed DNA polymerase activity
A0004518molecular_functionnuclease activity
A0004527molecular_functionexonuclease activity
A0004529molecular_functionDNA exonuclease activity
A0005515molecular_functionprotein binding
A0006260biological_processDNA replication
A0006261biological_processDNA-templated DNA replication
A0008152biological_processmetabolic process
A0008408molecular_function3'-5' exonuclease activity
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0016787molecular_functionhydrolase activity
A0039693biological_processviral DNA genome replication
A0046872molecular_functionmetal ion binding
A0090592biological_processDNA synthesis involved in DNA replication
A0097681biological_processdouble-strand break repair via alternative nonhomologous end joining
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0015035molecular_functionprotein-disulfide reductase activity
B0015036molecular_functiondisulfide oxidoreductase activity
B0030337molecular_functionDNA polymerase processivity factor activity
B0045454biological_processcell redox homeostasis
F0000166molecular_functionnucleotide binding
F0003676molecular_functionnucleic acid binding
F0003677molecular_functionDNA binding
F0003824molecular_functioncatalytic activity
F0003887molecular_functionDNA-directed DNA polymerase activity
F0004518molecular_functionnuclease activity
F0004527molecular_functionexonuclease activity
F0004529molecular_functionDNA exonuclease activity
F0005515molecular_functionprotein binding
F0006260biological_processDNA replication
F0006261biological_processDNA-templated DNA replication
F0008152biological_processmetabolic process
F0008408molecular_function3'-5' exonuclease activity
F0016740molecular_functiontransferase activity
F0016779molecular_functionnucleotidyltransferase activity
F0016787molecular_functionhydrolase activity
F0039693biological_processviral DNA genome replication
F0046872molecular_functionmetal ion binding
F0090592biological_processDNA synthesis involved in DNA replication
F0097681biological_processdouble-strand break repair via alternative nonhomologous end joining
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0015035molecular_functionprotein-disulfide reductase activity
I0015036molecular_functiondisulfide oxidoreductase activity
I0030337molecular_functionDNA polymerase processivity factor activity
I0045454biological_processcell redox homeostasis
Functional Information from PROSITE/UniProt
site_idPS00194
Number of Residues19
DetailsTHIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCGPCKmIapiL
ChainResidueDetails
BLEU24-LEU42

site_idPS00447
Number of Residues20
DetailsDNA_POLYMERASE_A DNA polymerase family A signature. RdnAKtfiYGflYgaGdekI
ChainResidueDetails
AARG518-ILE537

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Nucleophile
ChainResidueDetails
BGLY33
BLYS36
IGLY33
ILYS36
FALA7
FASP174

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Deprotonates C-terminal active site Cys
ChainResidueDetails
BPHE27
IPHE27
AASP654
FASP475
FALA476
FASP654

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Contributes to redox potential value
ChainResidueDetails
BPRO34
BCYS35
IPRO34
ICYS35
FHIS506
FARG518
FLYS522
FTYR526

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842
ChainResidueDetails
BTYR70
ITYR70

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon