2AHS
Crystal Structure of the Catalytic Domain of Human Tyrosine Receptor Phosphatase Beta
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 801 |
| Chain | Residue |
| B | GLU1726 |
| B | CYS1754 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 803 |
| Chain | Residue |
| A | ARG1770 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 804 |
| Chain | Residue |
| B | GLU1840 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 805 |
| Chain | Residue |
| B | SER1834 |
| B | SER1836 |
| B | ILE1843 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 807 |
| Chain | Residue |
| A | LEU1723 |
| A | HOH201 |
| A | ASP1720 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 808 |
| Chain | Residue |
| A | HOH71 |
| B | ARG1732 |
| B | TYR1733 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 809 |
| Chain | Residue |
| B | GLN1717 |
| B | LEU1941 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 810 |
| Chain | Residue |
| B | LYS1788 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA A 811 |
| Chain | Residue |
| A | ALA1741 |
| A | ARG1743 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 722 |
| Chain | Residue |
| A | HOH344 |
| A | HOH650 |
| A | CYS1719 |
| A | ASN1735 |
| A | ILE1736 |
| A | LEU1737 |
| A | VAL1944 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 725 |
| Chain | Residue |
| A | TYR1733 |
| A | ASN1735 |
| A | ILE1736 |
| A | GLN1948 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 726 |
| Chain | Residue |
| A | HOH518 |
| A | HOH595 |
| A | VAL1873 |
| A | PRO1874 |
| A | GLU1875 |
| A | TYR1955 |
| A | GLN1958 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 728 |
| Chain | Residue |
| B | PRO1839 |
| B | GLU1840 |
| B | TRP1841 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 729 |
| Chain | Residue |
| A | ALA1856 |
| A | ARG1858 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 734 |
| Chain | Residue |
| B | CYS1719 |
| B | ASN1735 |
| B | ILE1736 |
| B | LEU1737 |
| B | VAL1944 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 737 |
| Chain | Residue |
| B | GLY1765 |
| B | PHE1768 |
| B | ARG1769 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 741 |
| Chain | Residue |
| A | HOH637 |
| B | HOH213 |
| B | ALA1741 |
| B | ARG1770 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRTG |
| Chain | Residue | Details |
| A | VAL1902-GLY1912 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 260 |
| Details | Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10044","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17139078","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| A | ARG1910 | |
| A | GLU1806 | |
| A | CYS1904 | |
| A | ASP1870 | |
| A | THR1911 | |
| A | HIS1903 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| B | ARG1910 | |
| B | GLU1806 | |
| B | CYS1904 | |
| B | ASP1870 | |
| B | THR1911 | |
| B | HIS1903 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| A | ARG1910 | |
| A | CYS1904 | |
| A | ASP1870 | |
| A | THR1911 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| B | ARG1910 | |
| B | CYS1904 | |
| B | ASP1870 | |
| B | THR1911 |
