2AG4
Crystal Structure Analysis of GM2-activator protein complexed with phosphatidylcholine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001573 | biological_process | ganglioside metabolic process |
| A | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| A | 0005319 | molecular_function | lipid transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005764 | cellular_component | lysosome |
| A | 0006689 | biological_process | ganglioside catabolic process |
| A | 0006869 | biological_process | lipid transport |
| A | 0008047 | molecular_function | enzyme activator activity |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0016004 | molecular_function | phospholipase activator activity |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0030290 | molecular_function | sphingolipid activator protein activity |
| A | 0032428 | molecular_function | beta-N-acetylgalactosaminidase activity |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0046479 | biological_process | glycosphingolipid catabolic process |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0160317 | cellular_component | endolysosomal intralumenal vesicle membrane |
| A | 7770043 | ||
| B | 0001573 | biological_process | ganglioside metabolic process |
| B | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| B | 0005319 | molecular_function | lipid transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005764 | cellular_component | lysosome |
| B | 0006689 | biological_process | ganglioside catabolic process |
| B | 0006869 | biological_process | lipid transport |
| B | 0008047 | molecular_function | enzyme activator activity |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0016004 | molecular_function | phospholipase activator activity |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0030290 | molecular_function | sphingolipid activator protein activity |
| B | 0032428 | molecular_function | beta-N-acetylgalactosaminidase activity |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0043202 | cellular_component | lysosomal lumen |
| B | 0046479 | biological_process | glycosphingolipid catabolic process |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0160317 | cellular_component | endolysosomal intralumenal vesicle membrane |
| B | 7770043 |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE LP3 A 2341 |
| Chain | Residue |
| A | ALA17 |
| A | LEU145 |
| A | ILE155 |
| A | IPA1501 |
| A | HOH3686 |
| A | GLY41 |
| A | SER42 |
| A | THR43 |
| A | LEU47 |
| A | PRO97 |
| A | PRO106 |
| A | PHE111 |
| A | TYR116 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE LP3 B 2342 |
| Chain | Residue |
| B | ALA17 |
| B | ILE19 |
| B | GLY41 |
| B | SER42 |
| B | LEU47 |
| B | LEU89 |
| B | PRO97 |
| B | PRO106 |
| B | PHE111 |
| B | TYR116 |
| B | LEU145 |
| B | ILE155 |
| B | IPA1507 |
| B | IPA1510 |
| B | HOH3950 |
| B | HOH3953 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE OLA A 3628 |
| Chain | Residue |
| A | LEU37 |
| A | IPA1501 |
| A | HOH3888 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE OLA B 3629 |
| Chain | Residue |
| B | LEU37 |
| B | IPA1507 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IPA A 1501 |
| Chain | Residue |
| A | VAL39 |
| A | TYR116 |
| A | LEU118 |
| A | LP32341 |
| A | OLA3628 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IPA A 1502 |
| Chain | Residue |
| A | SER143 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IPA A 1503 |
| Chain | Residue |
| A | IPA1506 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IPA A 1506 |
| Chain | Residue |
| A | IPA1503 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IPA B 1505 |
| Chain | Residue |
| B | TYR139 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IPA B 1507 |
| Chain | Residue |
| B | VAL39 |
| B | GLY41 |
| B | TYR116 |
| B | LP32342 |
| B | OLA3629 |
| B | HOH3837 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IPA B 1510 |
| Chain | Residue |
| B | PHE82 |
| B | LP32342 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IPA B 1512 |
| Chain | Residue |
| B | HOH3918 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IPA B 1513 |
| Chain | Residue |
| B | PHE123 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"} |
| Chain | Residue | Details |
