2AD6
crystal structure of methanol dehydrogenase from M. W3A1 (form C)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0015945 | biological_process | methanol metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052933 | molecular_function | alcohol dehydrogenase (cytochrome c(L)) activity |
| B | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0015945 | biological_process | methanol metabolic process |
| B | 0015946 | biological_process | methanol oxidation |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0052933 | molecular_function | alcohol dehydrogenase (cytochrome c(L)) activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0015945 | biological_process | methanol metabolic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
| C | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0052933 | molecular_function | alcohol dehydrogenase (cytochrome c(L)) activity |
| D | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0015945 | biological_process | methanol metabolic process |
| D | 0015946 | biological_process | methanol oxidation |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0052933 | molecular_function | alcohol dehydrogenase (cytochrome c(L)) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 702 |
| Chain | Residue |
| A | GLU171 |
| A | ASN255 |
| A | ASP297 |
| A | PQQ701 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 704 |
| Chain | Residue |
| C | GLU171 |
| C | ASN255 |
| C | ASP297 |
| C | PQQ703 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE PQQ A 701 |
| Chain | Residue |
| A | CYS103 |
| A | CYS104 |
| A | VAL107 |
| A | ARG109 |
| A | THR153 |
| A | SER168 |
| A | GLY169 |
| A | ALA170 |
| A | GLU171 |
| A | THR235 |
| A | TRP237 |
| A | ASN255 |
| A | ARG324 |
| A | ASN387 |
| A | TRP467 |
| A | GLY530 |
| A | TRP531 |
| A | CA702 |
| A | HOH1501 |
| A | HOH2238 |
| A | HOH4001 |
| A | GLU55 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE PQQ C 703 |
| Chain | Residue |
| C | GLU55 |
| C | CYS103 |
| C | CYS104 |
| C | VAL107 |
| C | ARG109 |
| C | THR153 |
| C | SER168 |
| C | GLY169 |
| C | ALA170 |
| C | GLU171 |
| C | THR235 |
| C | TRP237 |
| C | ASN255 |
| C | ARG324 |
| C | ASN387 |
| C | TRP467 |
| C | GLY530 |
| C | TRP531 |
| C | CA704 |
| C | HOH1876 |
| C | HOH1914 |
| C | HOH4002 |
Functional Information from PROSITE/UniProt
| site_id | PS00364 |
| Number of Residues | 22 |
| Details | BACTERIAL_PQQ_2 Bacterial quinoprotein dehydrogenases signature 2. WgwyaYDpklNLFYYgsGnpAP |
| Chain | Residue | Details |
| A | TRP237-PRO258 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | ASP297 | |
| C | ASP297 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLU171 | |
| A | ASN255 | |
| C | GLU171 | |
| C | ASN255 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g72 |
| Chain | Residue | Details |
| A | ASP297 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g72 |
| Chain | Residue | Details |
| C | ASP297 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 99 |
| Chain | Residue | Details |
| A | GLU171 | metal ligand, proton acceptor, proton donor |
| A | ASN255 | metal ligand |
| A | ASP297 | metal ligand, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 99 |
| Chain | Residue | Details |
| C | GLU171 | metal ligand, proton acceptor, proton donor |
| C | ASN255 | metal ligand |
| C | ASP297 | metal ligand, proton acceptor, proton donor |
