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2ABM

Crystal Structure of Aquaporin Z Tetramer Reveals both Open and Closed Water-conducting Channels

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006833biological_processwater transport
A0006970biological_processresponse to osmotic stress
A0009992biological_processintracellular water homeostasis
A0015250molecular_functionwater channel activity
A0015267molecular_functionchannel activity
A0016020cellular_componentmembrane
A0042802molecular_functionidentical protein binding
A0055085biological_processtransmembrane transport
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006833biological_processwater transport
B0006970biological_processresponse to osmotic stress
B0009992biological_processintracellular water homeostasis
B0015250molecular_functionwater channel activity
B0015267molecular_functionchannel activity
B0016020cellular_componentmembrane
B0042802molecular_functionidentical protein binding
B0055085biological_processtransmembrane transport
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006833biological_processwater transport
C0006970biological_processresponse to osmotic stress
C0009992biological_processintracellular water homeostasis
C0015250molecular_functionwater channel activity
C0015267molecular_functionchannel activity
C0016020cellular_componentmembrane
C0042802molecular_functionidentical protein binding
C0055085biological_processtransmembrane transport
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006833biological_processwater transport
D0006970biological_processresponse to osmotic stress
D0009992biological_processintracellular water homeostasis
D0015250molecular_functionwater channel activity
D0015267molecular_functionchannel activity
D0016020cellular_componentmembrane
D0042802molecular_functionidentical protein binding
D0055085biological_processtransmembrane transport
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0006833biological_processwater transport
E0006970biological_processresponse to osmotic stress
E0009992biological_processintracellular water homeostasis
E0015250molecular_functionwater channel activity
E0015267molecular_functionchannel activity
E0016020cellular_componentmembrane
E0042802molecular_functionidentical protein binding
E0055085biological_processtransmembrane transport
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0006833biological_processwater transport
F0006970biological_processresponse to osmotic stress
F0009992biological_processintracellular water homeostasis
F0015250molecular_functionwater channel activity
F0015267molecular_functionchannel activity
F0016020cellular_componentmembrane
F0042802molecular_functionidentical protein binding
F0055085biological_processtransmembrane transport
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0006833biological_processwater transport
G0006970biological_processresponse to osmotic stress
G0009992biological_processintracellular water homeostasis
G0015250molecular_functionwater channel activity
G0015267molecular_functionchannel activity
G0016020cellular_componentmembrane
G0042802molecular_functionidentical protein binding
G0055085biological_processtransmembrane transport
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0006833biological_processwater transport
H0006970biological_processresponse to osmotic stress
H0009992biological_processintracellular water homeostasis
H0015250molecular_functionwater channel activity
H0015267molecular_functionchannel activity
H0016020cellular_componentmembrane
H0042802molecular_functionidentical protein binding
H0055085biological_processtransmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00221
Number of Residues9
DetailsMIP MIP family signature. HFNPAVTIG
ChainResidueDetails
AHIS61-GLY69

site_idPS00501
Number of Residues8
DetailsSPASE_I_1 Signal peptidases I serine active site. GYSMLSAL
ChainResidueDetails
AGLY128-LEU135

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues288
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues160
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues432
DetailsTopological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues160
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues160
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues160
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues160
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues160
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues16
DetailsMotif: {"description":"NPA 1"}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues16
DetailsMotif: {"description":"NPA 2"}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues8
DetailsSite: {"description":"Involved in tetramerization or stability of the tetramer"}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues32
DetailsSite: {"description":"Selectivity filter"}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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