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2ABM

Crystal Structure of Aquaporin Z Tetramer Reveals both Open and Closed Water-conducting Channels

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006833biological_processwater transport
A0006970biological_processresponse to osmotic stress
A0009992biological_processintracellular water homeostasis
A0015250molecular_functionwater channel activity
A0015267molecular_functionchannel activity
A0016020cellular_componentmembrane
A0042802molecular_functionidentical protein binding
A0055085biological_processtransmembrane transport
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006833biological_processwater transport
B0006970biological_processresponse to osmotic stress
B0009992biological_processintracellular water homeostasis
B0015250molecular_functionwater channel activity
B0015267molecular_functionchannel activity
B0016020cellular_componentmembrane
B0042802molecular_functionidentical protein binding
B0055085biological_processtransmembrane transport
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006833biological_processwater transport
C0006970biological_processresponse to osmotic stress
C0009992biological_processintracellular water homeostasis
C0015250molecular_functionwater channel activity
C0015267molecular_functionchannel activity
C0016020cellular_componentmembrane
C0042802molecular_functionidentical protein binding
C0055085biological_processtransmembrane transport
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006833biological_processwater transport
D0006970biological_processresponse to osmotic stress
D0009992biological_processintracellular water homeostasis
D0015250molecular_functionwater channel activity
D0015267molecular_functionchannel activity
D0016020cellular_componentmembrane
D0042802molecular_functionidentical protein binding
D0055085biological_processtransmembrane transport
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0006833biological_processwater transport
E0006970biological_processresponse to osmotic stress
E0009992biological_processintracellular water homeostasis
E0015250molecular_functionwater channel activity
E0015267molecular_functionchannel activity
E0016020cellular_componentmembrane
E0042802molecular_functionidentical protein binding
E0055085biological_processtransmembrane transport
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0006833biological_processwater transport
F0006970biological_processresponse to osmotic stress
F0009992biological_processintracellular water homeostasis
F0015250molecular_functionwater channel activity
F0015267molecular_functionchannel activity
F0016020cellular_componentmembrane
F0042802molecular_functionidentical protein binding
F0055085biological_processtransmembrane transport
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0006833biological_processwater transport
G0006970biological_processresponse to osmotic stress
G0009992biological_processintracellular water homeostasis
G0015250molecular_functionwater channel activity
G0015267molecular_functionchannel activity
G0016020cellular_componentmembrane
G0042802molecular_functionidentical protein binding
G0055085biological_processtransmembrane transport
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0006833biological_processwater transport
H0006970biological_processresponse to osmotic stress
H0009992biological_processintracellular water homeostasis
H0015250molecular_functionwater channel activity
H0015267molecular_functionchannel activity
H0016020cellular_componentmembrane
H0042802molecular_functionidentical protein binding
H0055085biological_processtransmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00221
Number of Residues9
DetailsMIP MIP family signature. HFNPAVTIG
ChainResidueDetails
AHIS61-GLY69

site_idPS00501
Number of Residues8
DetailsSPASE_I_1 Signal peptidases I serine active site. GYSMLSAL
ChainResidueDetails
AGLY128-LEU135

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues352
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-GLU8
CGLY55-VAL81
CALA152-LYS155
CTYR223-ASP231
DMET1-GLU8
DGLY55-VAL81
DALA152-LYS155
DTYR223-ASP231
EMET1-GLU8
EGLY55-VAL81
EALA152-LYS155
AGLY55-VAL81
ETYR223-ASP231
FMET1-GLU8
FGLY55-VAL81
FALA152-LYS155
FTYR223-ASP231
GMET1-GLU8
GGLY55-VAL81
GALA152-LYS155
GTYR223-ASP231
HMET1-GLU8
AALA152-LYS155
HGLY55-VAL81
HALA152-LYS155
HTYR223-ASP231
ATYR223-ASP231
BMET1-GLU8
BGLY55-VAL81
BALA152-LYS155
BTYR223-ASP231
CMET1-GLU8

site_idSWS_FT_FI2
Number of Residues160
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
ACYS9-PHE29
BCYS9-PHE29
CCYS9-PHE29
DCYS9-PHE29
ECYS9-PHE29
FCYS9-PHE29
GCYS9-PHE29
HCYS9-PHE29

site_idSWS_FT_FI3
Number of Residues432
DetailsTOPO_DOM: Periplasmic => ECO:0000255
ChainResidueDetails
APRO30-GLY33
DPRO30-GLY33
DALA103-SER130
DSER177-ALA201
EPRO30-GLY33
EALA103-SER130
ESER177-ALA201
FPRO30-GLY33
FALA103-SER130
FSER177-ALA201
GPRO30-GLY33
AALA103-SER130
GALA103-SER130
GSER177-ALA201
HPRO30-GLY33
HALA103-SER130
HSER177-ALA201
ASER177-ALA201
BPRO30-GLY33
BALA103-SER130
BSER177-ALA201
CPRO30-GLY33
CALA103-SER130
CSER177-ALA201

site_idSWS_FT_FI4
Number of Residues160
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
AILE34-VAL54
BILE34-VAL54
CILE34-VAL54
DILE34-VAL54
EILE34-VAL54
FILE34-VAL54
GILE34-VAL54
HILE34-VAL54

site_idSWS_FT_FI5
Number of Residues160
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
AVAL82-ILE102
BVAL82-ILE102
CVAL82-ILE102
DVAL82-ILE102
EVAL82-ILE102
FVAL82-ILE102
GVAL82-ILE102
HVAL82-ILE102

site_idSWS_FT_FI6
Number of Residues160
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
AMET131-GLY151
BMET131-GLY151
CMET131-GLY151
DMET131-GLY151
EMET131-GLY151
FMET131-GLY151
GMET131-GLY151
HMET131-GLY151

site_idSWS_FT_FI7
Number of Residues160
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
APHE156-ILE176
BPHE156-ILE176
CPHE156-ILE176
DPHE156-ILE176
EPHE156-ILE176
FPHE156-ILE176
GPHE156-ILE176
HPHE156-ILE176

site_idSWS_FT_FI8
Number of Residues160
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
ALEU202-ILE222
BLEU202-ILE222
CLEU202-ILE222
DLEU202-ILE222
ELEU202-ILE222
FLEU202-ILE222
GLEU202-ILE222
HLEU202-ILE222

site_idSWS_FT_FI9
Number of Residues8
DetailsSITE: Involved in tetramerization or stability of the tetramer
ChainResidueDetails
ACYS20
BCYS20
CCYS20
DCYS20
ECYS20
FCYS20
GCYS20
HCYS20

site_idSWS_FT_FI10
Number of Residues32
DetailsSITE: Selectivity filter
ChainResidueDetails
APHE43
CHIS174
CTHR183
CARG189
DPHE43
DHIS174
DTHR183
DARG189
EPHE43
EHIS174
ETHR183
AHIS174
EARG189
FPHE43
FHIS174
FTHR183
FARG189
GPHE43
GHIS174
GTHR183
GARG189
HPHE43
ATHR183
HHIS174
HTHR183
HARG189
AARG189
BPHE43
BHIS174
BTHR183
BARG189
CPHE43

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PDB entries from 2024-07-10

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