2AAW

Studies on ligand binding and enzyme inhibition of Plasmodium falciparum glutathione S-transferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0006749	biological_process	glutathione metabolic process
A	0016740	molecular_function	transferase activity
C	0004364	molecular_function	glutathione transferase activity
C	0006749	biological_process	glutathione metabolic process
C	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GTX A 220

Chain	Residue
A	TYR9
A	P33222
A	HOH223
A	HOH260
A	HOH263
A	HOH266
C	PHE42
C	LYS46
C	ASP105
A	LYS15
A	PHE45
A	GLN58
A	VAL59
A	GLN71
A	SER72
A	PHE116
A	TYR211

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GTX C 221

Chain	Residue
A	PHE42
A	ASP105
C	TYR9
C	LYS15
C	GLN58
C	VAL59
C	GLN71
C	SER72
C	TYR211
C	P33223
C	HOH232
C	HOH239
C	HOH263

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE P33 A 222

Chain	Residue
A	GLY14
A	LYS15
A	GLN104
A	HIS107
A	TYR108
A	ASN111
A	GTX220
C	TYR108
C	P33223
C	HOH295

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE P33 C 223

Chain	Residue
A	P33222
C	GLY14
C	LYS15
C	GLN104
C	HIS107
C	ASN111
C	GTX221
C	HOH263

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DTL C 224

Chain	Residue
A	HOH300
C	LEU26
C	HOH306

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305|PubMed:12972411

Chain	Residue	Details
A	GLN58
A	GLN71
A	LYS117
A	THR121
C	GLN58
C	GLN71
C	LYS117
C	THR121

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:3FR9

Chain	Residue	Details
A	ASP105
C	ASP105

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
A	TYR9

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
C	TYR9

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