2A8N

Biochemical and Structural Studies of A-to-I Editing by tRNA:A34 Deaminases at the Wobble Position of Transfer RNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002100	biological_process	tRNA wobble adenosine to inosine editing
A	0003824	molecular_function	catalytic activity
A	0008033	biological_process	tRNA processing
A	0008251	molecular_function	tRNA-specific adenosine deaminase activity
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0052717	molecular_function	tRNA-specific adenosine-34 deaminase activity
B	0002100	biological_process	tRNA wobble adenosine to inosine editing
B	0003824	molecular_function	catalytic activity
B	0008033	biological_process	tRNA processing
B	0008251	molecular_function	tRNA-specific adenosine deaminase activity
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	0052717	molecular_function	tRNA-specific adenosine-34 deaminase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	HIS53
A	CYS83
A	CYS86
A	HOH361

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 302

Chain	Residue
B	HIS53
B	CYS83
B	CYS86
B	HOH317

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Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	38
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAEiaVIrmacealgqerlpgadlyvtle...........PCtm......CaaaI

Chain	Residue	Details
A	HIS53-ILE90

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	109
Details	Domain: {"description":"CMP/dCMP-type deaminase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_00972","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16142903","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00972","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16142903","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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