2A7R
Crystal structure of human Guanosine Monophosphate reductase 2 (GMPR2)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0003920 | molecular_function | GMP reductase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005829 | cellular_component | cytosol |
A | 0006144 | biological_process | purine nucleobase metabolic process |
A | 0006163 | biological_process | purine nucleotide metabolic process |
A | 0009117 | biological_process | nucleotide metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046037 | biological_process | GMP metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 1902560 | cellular_component | GMP reductase complex |
B | 0003824 | molecular_function | catalytic activity |
B | 0003920 | molecular_function | GMP reductase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005829 | cellular_component | cytosol |
B | 0006144 | biological_process | purine nucleobase metabolic process |
B | 0006163 | biological_process | purine nucleotide metabolic process |
B | 0009117 | biological_process | nucleotide metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046037 | biological_process | GMP metabolic process |
B | 0046872 | molecular_function | metal ion binding |
B | 1902560 | cellular_component | GMP reductase complex |
C | 0003824 | molecular_function | catalytic activity |
C | 0003920 | molecular_function | GMP reductase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005829 | cellular_component | cytosol |
C | 0006144 | biological_process | purine nucleobase metabolic process |
C | 0006163 | biological_process | purine nucleotide metabolic process |
C | 0009117 | biological_process | nucleotide metabolic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0046037 | biological_process | GMP metabolic process |
C | 0046872 | molecular_function | metal ion binding |
C | 1902560 | cellular_component | GMP reductase complex |
D | 0003824 | molecular_function | catalytic activity |
D | 0003920 | molecular_function | GMP reductase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005829 | cellular_component | cytosol |
D | 0006144 | biological_process | purine nucleobase metabolic process |
D | 0006163 | biological_process | purine nucleotide metabolic process |
D | 0009117 | biological_process | nucleotide metabolic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0046037 | biological_process | GMP metabolic process |
D | 0046872 | molecular_function | metal ion binding |
D | 1902560 | cellular_component | GMP reductase complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 400 |
Chain | Residue |
A | THR33 |
A | ARG34 |
A | SER35 |
A | LYS325 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 401 |
Chain | Residue |
A | PHE149 |
A | PRO150 |
A | GLN151 |
A | HIS152 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 1400 |
Chain | Residue |
B | ARG34 |
B | SER35 |
B | LYS323 |
B | LYS325 |
B | THR33 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 1401 |
Chain | Residue |
B | PHE149 |
B | PRO150 |
B | GLN151 |
B | HIS152 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 2400 |
Chain | Residue |
C | THR33 |
C | ARG34 |
C | SER35 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 2401 |
Chain | Residue |
C | PHE149 |
C | PRO150 |
C | GLN151 |
C | HIS152 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 3400 |
Chain | Residue |
D | THR33 |
D | ARG34 |
D | SER35 |
D | LYS325 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 D 3500 |
Chain | Residue |
D | GLY183 |
D | SER184 |
D | GLY220 |
D | GLY221 |
D | CYS222 |
D | GLY242 |
D | GLY243 |
site_id | AC9 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE 5GP A 500 |
Chain | Residue |
A | MET55 |
A | GLY183 |
A | SER184 |
A | CYS186 |
A | THR188 |
A | ASP219 |
A | GLY220 |
A | GLY221 |
A | GLY242 |
A | GLY243 |
A | GLY268 |
A | MET269 |
A | SER270 |
A | ARG286 |
A | ALA287 |
A | SER288 |
A | GLY290 |
site_id | BC1 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 5GP B 500 |
Chain | Residue |
B | ALA53 |
B | MET55 |
B | GLY183 |
B | SER184 |
B | CYS186 |
B | THR188 |
B | ASP219 |
B | GLY220 |
B | GLY221 |
B | GLY242 |
B | GLY243 |
B | GLY268 |
B | SER270 |
B | ARG286 |
B | SER288 |
B | GLY290 |
site_id | BC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 5GP C 500 |
Chain | Residue |
C | ALA53 |
C | MET55 |
C | SER184 |
C | CYS186 |
C | THR188 |
C | ASP219 |
C | GLY220 |
C | GLY221 |
C | GLY242 |
C | GLY243 |
C | GLY268 |
C | MET269 |
C | SER270 |
C | GLY290 |
Functional Information from PROSITE/UniProt
site_id | PS00487 |
Number of Residues | 13 |
Details | IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. IKVGIGpGSVCtT |
Chain | Residue | Details |
A | ILE176-THR188 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_03195 |
Chain | Residue | Details |
A | CYS186 | |
B | CYS186 | |
C | CYS186 | |
D | CYS186 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_03195 |
Chain | Residue | Details |
A | THR188 | |
B | THR188 | |
C | THR188 | |
D | THR188 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03195, ECO:0000269|PubMed:22037469 |
Chain | Residue | Details |
A | SER26 | |
A | SER314 | |
B | SER26 | |
B | SER314 | |
C | SER26 | |
C | SER314 | |
D | SER26 | |
D | SER314 |
site_id | SWS_FT_FI4 |
Number of Residues | 20 |
Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_03195, ECO:0000269|PubMed:22037469 |
Chain | Residue | Details |
A | LYS78 | |
B | TYR285 | |
C | LYS78 | |
C | ASP129 | |
C | ILE180 | |
C | MET269 | |
C | TYR285 | |
D | LYS78 | |
D | ASP129 | |
D | ILE180 | |
D | MET269 | |
A | ASP129 | |
D | TYR285 | |
A | ILE180 | |
A | MET269 | |
A | TYR285 | |
B | LYS78 | |
B | ASP129 | |
B | ILE180 | |
B | MET269 |
site_id | SWS_FT_FI5 |
Number of Residues | 32 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03195 |
Chain | Residue | Details |
A | GLY181 | |
B | GLY183 | |
B | CYS186 | |
B | ARG189 | |
B | ASP219 | |
B | GLY242 | |
B | GLY268 | |
B | ARG286 | |
C | GLY181 | |
C | GLY183 | |
C | CYS186 | |
A | GLY183 | |
C | ARG189 | |
C | ASP219 | |
C | GLY242 | |
C | GLY268 | |
C | ARG286 | |
D | GLY181 | |
D | GLY183 | |
D | CYS186 | |
D | ARG189 | |
D | ASP219 | |
A | CYS186 | |
D | GLY242 | |
D | GLY268 | |
D | ARG286 | |
A | ARG189 | |
A | ASP219 | |
A | GLY242 | |
A | GLY268 | |
A | ARG286 | |
B | GLY181 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS291 | |
B | LYS291 | |
C | LYS291 | |
D | LYS291 |