2A7R

Crystal structure of human Guanosine Monophosphate reductase 2 (GMPR2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003920	molecular_function	GMP reductase activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006144	biological_process	purine nucleobase metabolic process
A	0006163	biological_process	purine nucleotide metabolic process
A	0009117	biological_process	nucleotide metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0046037	biological_process	GMP metabolic process
A	0046872	molecular_function	metal ion binding
A	1902560	cellular_component	GMP reductase complex
B	0003824	molecular_function	catalytic activity
B	0003920	molecular_function	GMP reductase activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006144	biological_process	purine nucleobase metabolic process
B	0006163	biological_process	purine nucleotide metabolic process
B	0009117	biological_process	nucleotide metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0046037	biological_process	GMP metabolic process
B	0046872	molecular_function	metal ion binding
B	1902560	cellular_component	GMP reductase complex
C	0003824	molecular_function	catalytic activity
C	0003920	molecular_function	GMP reductase activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0006144	biological_process	purine nucleobase metabolic process
C	0006163	biological_process	purine nucleotide metabolic process
C	0009117	biological_process	nucleotide metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0046037	biological_process	GMP metabolic process
C	0046872	molecular_function	metal ion binding
C	1902560	cellular_component	GMP reductase complex
D	0003824	molecular_function	catalytic activity
D	0003920	molecular_function	GMP reductase activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0006144	biological_process	purine nucleobase metabolic process
D	0006163	biological_process	purine nucleotide metabolic process
D	0009117	biological_process	nucleotide metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0046037	biological_process	GMP metabolic process
D	0046872	molecular_function	metal ion binding
D	1902560	cellular_component	GMP reductase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 400

Chain	Residue
A	THR33
A	ARG34
A	SER35
A	LYS325

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 401

Chain	Residue
A	PHE149
A	PRO150
A	GLN151
A	HIS152

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1400

Chain	Residue
B	ARG34
B	SER35
B	LYS323
B	LYS325
B	THR33

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1401

Chain	Residue
B	PHE149
B	PRO150
B	GLN151
B	HIS152

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 2400

Chain	Residue
C	THR33
C	ARG34
C	SER35

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 2401

Chain	Residue
C	PHE149
C	PRO150
C	GLN151
C	HIS152

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 3400

Chain	Residue
D	THR33
D	ARG34
D	SER35
D	LYS325

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 3500

Chain	Residue
D	GLY183
D	SER184
D	GLY220
D	GLY221
D	CYS222
D	GLY242
D	GLY243

---

site_id	AC9
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 5GP A 500

Chain	Residue
A	MET55
A	GLY183
A	SER184
A	CYS186
A	THR188
A	ASP219
A	GLY220
A	GLY221
A	GLY242
A	GLY243
A	GLY268
A	MET269
A	SER270
A	ARG286
A	ALA287
A	SER288
A	GLY290

---

site_id	BC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 5GP B 500

Chain	Residue
B	ALA53
B	MET55
B	GLY183
B	SER184
B	CYS186
B	THR188
B	ASP219
B	GLY220
B	GLY221
B	GLY242
B	GLY243
B	GLY268
B	SER270
B	ARG286
B	SER288
B	GLY290

---

site_id	BC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 5GP C 500

Chain	Residue
C	ALA53
C	MET55
C	SER184
C	CYS186
C	THR188
C	ASP219
C	GLY220
C	GLY221
C	GLY242
C	GLY243
C	GLY268
C	MET269
C	SER270
C	GLY290

---

Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. IKVGIGpGSVCtT

Chain	Residue	Details
A	ILE176-THR188

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Thioimidate intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_03195","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_03195","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03195","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22037469","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	21
Details	Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_03195","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22037469","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	38
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03195","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---