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2A5Y

Structure of a CED-4/CED-9 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0042981biological_processregulation of apoptotic process
B0000287molecular_functionmagnesium ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006915biological_processapoptotic process
B0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
B0008303cellular_componentcaspase complex
B0008361biological_processregulation of cell size
B0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
B0009792biological_processembryo development ending in birth or egg hatching
B0010954biological_processpositive regulation of protein processing
B0016020cellular_componentmembrane
B0016505molecular_functionpeptidase activator activity involved in apoptotic process
B0030042biological_processactin filament depolymerization
B0030155biological_processregulation of cell adhesion
B0031647biological_processregulation of protein stability
B0032991cellular_componentprotein-containing complex
B0040034biological_processregulation of development, heterochronic
B0042802molecular_functionidentical protein binding
B0042981biological_processregulation of apoptotic process
B0043065biological_processpositive regulation of apoptotic process
B0043531molecular_functionADP binding
B0046716biological_processmuscle cell cellular homeostasis
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0048598biological_processembryonic morphogenesis
B0050829biological_processdefense response to Gram-negative bacterium
B0051432molecular_functionBH1 domain binding
B0051434molecular_functionBH3 domain binding
B0061133molecular_functionendopeptidase activator activity
B0089720molecular_functioncaspase binding
B0097202biological_processactivation of cysteine-type endopeptidase activity
B1900118biological_processnegative regulation of execution phase of apoptosis
B1902742biological_processapoptotic process involved in development
B1904747biological_processpositive regulation of apoptotic process involved in development
B1905808biological_processpositive regulation of synapse pruning
C0000287molecular_functionmagnesium ion binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006915biological_processapoptotic process
C0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
C0008303cellular_componentcaspase complex
C0008361biological_processregulation of cell size
C0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
C0009792biological_processembryo development ending in birth or egg hatching
C0010954biological_processpositive regulation of protein processing
C0016020cellular_componentmembrane
C0016505molecular_functionpeptidase activator activity involved in apoptotic process
C0030042biological_processactin filament depolymerization
C0030155biological_processregulation of cell adhesion
C0031647biological_processregulation of protein stability
C0032991cellular_componentprotein-containing complex
C0040034biological_processregulation of development, heterochronic
C0042802molecular_functionidentical protein binding
C0042981biological_processregulation of apoptotic process
C0043065biological_processpositive regulation of apoptotic process
C0043531molecular_functionADP binding
C0046716biological_processmuscle cell cellular homeostasis
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0048598biological_processembryonic morphogenesis
C0050829biological_processdefense response to Gram-negative bacterium
C0051432molecular_functionBH1 domain binding
C0051434molecular_functionBH3 domain binding
C0061133molecular_functionendopeptidase activator activity
C0089720molecular_functioncaspase binding
C0097202biological_processactivation of cysteine-type endopeptidase activity
C1900118biological_processnegative regulation of execution phase of apoptosis
C1902742biological_processapoptotic process involved in development
C1904747biological_processpositive regulation of apoptotic process involved in development
C1905808biological_processpositive regulation of synapse pruning
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG B 550
ChainResidue
BSER166
BATP551
BHOH615

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG C 550
ChainResidue
CSER166
CASP250
CATP551

site_idAC3
Number of Residues18
DetailsBINDING SITE FOR RESIDUE ATP B 551
ChainResidue
BGLY162
BSER163
BGLY164
BLYS165
BSER166
BVAL167
BARG273
BTYR305
BPRO330
BALA331
BMET334
BPRO368
BTYR369
BMG550
BHOH652
BMET128
BTYR131
BALA161

site_idAC4
Number of Residues22
DetailsBINDING SITE FOR RESIDUE ATP C 551
ChainResidue
CMET128
CTYR131
CGLY162
CSER163
CGLY164
CLYS165
CSER166
CVAL167
CARG273
CPHE301
CTYR305
CPRO330
CALA331
CMET334
CPRO368
CTYR369
CMG550
CHOH552
CHOH553
CHOH580
CHOH581
CHOH608

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:16208361, ECO:0000269|PubMed:20434985, ECO:0000269|PubMed:24065769, ECO:0007744|PDB:2A5Y, ECO:0007744|PDB:3LQQ, ECO:0007744|PDB:3LQR, ECO:0007744|PDB:4M9S, ECO:0007744|PDB:4M9X, ECO:0007744|PDB:4M9Y, ECO:0007744|PDB:4M9Z
ChainResidueDetails
BTYR131
BGLY162
CTYR131
CGLY162

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:16208361, ECO:0000269|PubMed:20434985
ChainResidueDetails
BSER166
CSER166

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:24065769, ECO:0007744|PDB:4M9S
ChainResidueDetails
BGLN171
CGLN171

222415

PDB entries from 2024-07-10

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