Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2A5Y

Structure of a CED-4/CED-9 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042981	biological_process	regulation of apoptotic process
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006915	biological_process	apoptotic process
B	0008303	cellular_component	caspase complex
B	0008361	biological_process	regulation of cell size
B	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
B	0009792	biological_process	embryo development ending in birth or egg hatching
B	0010954	biological_process	positive regulation of protein processing
B	0016020	cellular_component	membrane
B	0016505	molecular_function	peptidase activator activity involved in apoptotic process
B	0030042	biological_process	actin filament depolymerization
B	0030155	biological_process	regulation of cell adhesion
B	0031647	biological_process	regulation of protein stability
B	0032991	cellular_component	protein-containing complex
B	0040034	biological_process	regulation of development, heterochronic
B	0042802	molecular_function	identical protein binding
B	0042981	biological_process	regulation of apoptotic process
B	0043065	biological_process	positive regulation of apoptotic process
B	0043531	molecular_function	ADP binding
B	0046716	biological_process	muscle cell cellular homeostasis
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0048598	biological_process	embryonic morphogenesis
B	0050829	biological_process	defense response to Gram-negative bacterium
B	0051432	molecular_function	BH1 domain binding
B	0051434	molecular_function	BH3 domain binding
B	0061133	molecular_function	endopeptidase activator activity
B	0089720	molecular_function	caspase binding
B	0140608	molecular_function	cysteine-type endopeptidase activator activity
B	1900118	biological_process	negative regulation of execution phase of apoptosis
B	1902742	biological_process	apoptotic process involved in development
B	1904747	biological_process	positive regulation of apoptotic process involved in development
B	1905808	biological_process	positive regulation of synapse pruning
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006915	biological_process	apoptotic process
C	0008303	cellular_component	caspase complex
C	0008361	biological_process	regulation of cell size
C	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
C	0009792	biological_process	embryo development ending in birth or egg hatching
C	0010954	biological_process	positive regulation of protein processing
C	0016020	cellular_component	membrane
C	0016505	molecular_function	peptidase activator activity involved in apoptotic process
C	0030042	biological_process	actin filament depolymerization
C	0030155	biological_process	regulation of cell adhesion
C	0031647	biological_process	regulation of protein stability
C	0032991	cellular_component	protein-containing complex
C	0040034	biological_process	regulation of development, heterochronic
C	0042802	molecular_function	identical protein binding
C	0042981	biological_process	regulation of apoptotic process
C	0043065	biological_process	positive regulation of apoptotic process
C	0043531	molecular_function	ADP binding
C	0046716	biological_process	muscle cell cellular homeostasis
C	0046872	molecular_function	metal ion binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0048598	biological_process	embryonic morphogenesis
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0051432	molecular_function	BH1 domain binding
C	0051434	molecular_function	BH3 domain binding
C	0061133	molecular_function	endopeptidase activator activity
C	0089720	molecular_function	caspase binding
C	0140608	molecular_function	cysteine-type endopeptidase activator activity
C	1900118	biological_process	negative regulation of execution phase of apoptosis
C	1902742	biological_process	apoptotic process involved in development
C	1904747	biological_process	positive regulation of apoptotic process involved in development
C	1905808	biological_process	positive regulation of synapse pruning

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 550

Chain	Residue
B	SER166
B	ATP551
B	HOH615

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 550

Chain	Residue
C	SER166
C	ASP250
C	ATP551

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ATP B 551

Chain	Residue
B	GLY162
B	SER163
B	GLY164
B	LYS165
B	SER166
B	VAL167
B	ARG273
B	TYR305
B	PRO330
B	ALA331
B	MET334
B	PRO368
B	TYR369
B	MG550
B	HOH652
B	MET128
B	TYR131
B	ALA161

site_id	AC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ATP C 551

Chain	Residue
C	MET128
C	TYR131
C	GLY162
C	SER163
C	GLY164
C	LYS165
C	SER166
C	VAL167
C	ARG273
C	PHE301
C	TYR305
C	PRO330
C	ALA331
C	MET334
C	PRO368
C	TYR369
C	MG550
C	HOH552
C	HOH553
C	HOH580
C	HOH581
C	HOH608

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	Motif: {"description":"BH4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00025","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Motif: {"description":"BH2","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	90
Details	Domain: {"description":"CARD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00046","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37402593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JOL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37402593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JOL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37402593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JOL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37402593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JOL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)