Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2A27

Human DRP-1 kinase, W305S S308A D40 mutant, crystal form with 8 monomers in the asymmetric unit

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
E	0004672	molecular_function	protein kinase activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation
F	0004672	molecular_function	protein kinase activity
F	0005524	molecular_function	ATP binding
F	0006468	biological_process	protein phosphorylation
G	0004672	molecular_function	protein kinase activity
G	0005524	molecular_function	ATP binding
G	0006468	biological_process	protein phosphorylation
H	0004672	molecular_function	protein kinase activity
H	0005524	molecular_function	ATP binding
H	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DTT A 1001

Chain	Residue
A	PHE178
A	GLY179
A	LYS222
A	HOH1018
E	DTT1005

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DTT B 1002

Chain	Residue
B	PHE178
B	GLY179
B	HOH1051
C	DTT1003

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DTT C 1003

Chain	Residue
B	DTT1002
C	PHE178
C	GLY179
C	LYS222
C	HOH1036
C	HOH1043

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DTT E 1005

Chain	Residue
A	DTT1001
E	PHE178
E	GLY179
E	HOH1007

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DTT D 1004

Chain	Residue
D	PHE178
D	GLY179
D	LYS222
D	LEU226
D	HOH1007
G	DTT1006

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DTT G 1006

Chain	Residue
D	ILE177
D	DTT1004
G	GLY179
G	LYS222

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DTT F 1007

Chain	Residue
F	PHE178
F	GLY179
F	PRO181
F	HOH1010
H	ILE177
H	DTT1008

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DTT H 1008

Chain	Residue
F	ILE177
F	DTT1007
H	PHE178
H	GLY179

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	28
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGQFAIVKkCrekstgleyaak......FIKK

Chain	Residue	Details
A	LEU19-LYS46

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHfDLKpeNIML

Chain	Residue	Details
A	ILE135-LEU147

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP139
B	ASP139
C	ASP139
D	ASP139
E	ASP139
F	ASP139
G	ASP139
H	ASP139

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU19
B	LEU19
C	LEU19
D	LEU19
E	LEU19
F	LEU19
G	LEU19
H	LEU19

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000269\|PubMed:10376525, ECO:0000269\|PubMed:10629061

Chain	Residue	Details
A	LYS42
B	LYS42
C	LYS42
D	LYS42
E	LYS42
F	LYS42
G	LYS42
H	LYS42

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER289
B	SER289
C	SER289
D	SER289
E	SER289
F	SER289
G	SER289
H	SER289

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269\|PubMed:11230133

Chain	Residue	Details
A	ALA308
B	ALA308
C	ALA308
D	ALA308
E	ALA308
F	ALA308
G	ALA308
H	ALA308

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	GLU143
A	ASP139

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP139
B	LYS141

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP139
C	LYS141

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP139
D	LYS141

site_id	CSA13
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ASP139
E	LYS141

site_id	CSA14
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	ASP139
F	LYS141

site_id	CSA15
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
G	ASP139
G	LYS141

site_id	CSA16
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
H	ASP139
H	LYS141

site_id	CSA17
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	THR180
A	ASP139
A	LYS141

site_id	CSA18
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	THR180
B	ASP139
B	LYS141

site_id	CSA19
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	THR180
C	ASP139
C	LYS141

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	GLU143
B	ASP139

site_id	CSA20
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	THR180
D	ASP139
D	LYS141

site_id	CSA21
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	THR180
E	ASP139
E	LYS141

site_id	CSA22
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	THR180
F	ASP139
F	LYS141

site_id	CSA23
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
G	THR180
G	ASP139
G	LYS141

site_id	CSA24
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
H	THR180
H	ASP139
H	LYS141

site_id	CSA25
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP139
A	LYS141
A	ASN144

site_id	CSA26
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP139
B	LYS141
B	ASN144

site_id	CSA27
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP139
C	LYS141
C	ASN144

site_id	CSA28
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP139
D	LYS141
D	ASN144

site_id	CSA29
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ASP139
E	LYS141
E	ASN144

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	GLU143
C	ASP139

site_id	CSA30
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	ASP139
F	LYS141
F	ASN144

site_id	CSA31
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
G	ASP139
G	LYS141
G	ASN144

site_id	CSA32
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
H	ASP139
H	LYS141
H	ASN144

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	GLU143
D	ASP139

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	GLU143
E	ASP139

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	GLU143
F	ASP139

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
G	GLU143
G	ASP139

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
H	GLU143
H	ASP139

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP139
A	LYS141

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)