2A0U
Crystal structure of the eukaryotic initiation factor 2B from Leishmania major at 2.1 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019284 | biological_process | L-methionine salvage from S-adenosylmethionine |
| A | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| A | 0044237 | biological_process | cellular metabolic process |
| A | 0044249 | biological_process | cellular biosynthetic process |
| A | 0046523 | molecular_function | S-methyl-5-thioribose-1-phosphate isomerase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019284 | biological_process | L-methionine salvage from S-adenosylmethionine |
| B | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| B | 0044237 | biological_process | cellular metabolic process |
| B | 0044249 | biological_process | cellular biosynthetic process |
| B | 0046523 | molecular_function | S-methyl-5-thioribose-1-phosphate isomerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 401 |
| Chain | Residue |
| A | ARG119 |
| A | ARG266 |
| A | HOH553 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 402 |
| Chain | Residue |
| A | HOH423 |
| A | MSE58 |
| A | ARG61 |
| A | GLY62 |
| A | ARG108 |
| A | GLN224 |
| A | LYS276 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 403 |
| Chain | Residue |
| A | THR47 |
| A | VAL48 |
| A | GLU49 |
| A | LYS81 |
| A | PHE96 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 404 |
| Chain | Residue |
| A | ARG255 |
| B | SER340 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 405 |
| Chain | Residue |
| A | ARG255 |
| A | HOH427 |
| B | TRP342 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 406 |
| Chain | Residue |
| A | LYS12 |
| A | LYS22 |
| B | THR47 |
| B | VAL48 |
| B | GLU49 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 407 |
| Chain | Residue |
| B | ARG119 |
| B | ARG266 |
| B | HOH519 |
| B | HOH537 |
| B | HOH541 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 408 |
| Chain | Residue |
| B | MSE58 |
| B | ARG61 |
| B | GLY62 |
| B | ARG108 |
| B | GLN224 |
| B | LYS276 |
| B | PHE346 |
| B | HOH438 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 409 |
| Chain | Residue |
| A | SER340 |
| B | ARG255 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 B 410 |
| Chain | Residue |
| B | ARG255 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_03119 |
| Chain | Residue | Details |
| A | ALA134 | |
| B | ALA134 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_03119 |
| Chain | Residue | Details |
| A | ALA54 | |
| B | ALA54 |
