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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

28KE

Cryo-EM structure of the human holo-TFIIH-XPC-XPA complex bound to bulky lesion-mimic DNA

Functional Information from GO Data
ChainGOidnamespacecontents
A0000112cellular_componentnucleotide-excision repair factor 3 complex
A0000439cellular_componenttranscription factor TFIIH core complex
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005669cellular_componenttranscription factor TFIID complex
A0005675cellular_componenttranscription factor TFIIH holo complex
A0006265biological_processDNA topological change
A0006281biological_processDNA repair
A0006283biological_processtranscription-coupled nucleotide-excision repair
A0006289biological_processnucleotide-excision repair
A0006366biological_processtranscription by RNA polymerase II
A0006367biological_processtranscription initiation at RNA polymerase II promoter
A0006368biological_processtranscription elongation by RNA polymerase II
A0006915biological_processapoptotic process
A0006979biological_processresponse to oxidative stress
A0008104biological_processintracellular protein localization
A0009411biological_processresponse to UV
A0016887molecular_functionATP hydrolysis activity
A0035315biological_processhair cell differentiation
A0043065biological_processpositive regulation of apoptotic process
A0043138molecular_function3'-5' DNA helicase activity
A0048568biological_processembryonic organ development
A0097550cellular_componenttranscription preinitiation complex
A1901990biological_processregulation of mitotic cell cycle phase transition
A1990841molecular_functionpromoter-specific chromatin binding
B0000439cellular_componenttranscription factor TFIIH core complex
B0001666biological_processresponse to hypoxia
B0003678molecular_functionDNA helicase activity
B0003684molecular_functiondamaged DNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005669cellular_componenttranscription factor TFIID complex
B0005675cellular_componenttranscription factor TFIIH holo complex
B0005737cellular_componentcytoplasm
B0005819cellular_componentspindle
B0006283biological_processtranscription-coupled nucleotide-excision repair
B0006289biological_processnucleotide-excision repair
B0006357biological_processregulation of transcription by RNA polymerase II
B0006366biological_processtranscription by RNA polymerase II
B0006367biological_processtranscription initiation at RNA polymerase II promoter
B0006915biological_processapoptotic process
B0006979biological_processresponse to oxidative stress
B0007059biological_processchromosome segregation
B0016887molecular_functionATP hydrolysis activity
B0030674molecular_functionprotein-macromolecule adaptor activity
B0035315biological_processhair cell differentiation
B0043139molecular_function5'-3' DNA helicase activity
B0048568biological_processembryonic organ development
B0070516cellular_componentCAK-ERCC2 complex
B0071817cellular_componentMMXD complex
B1901990biological_processregulation of mitotic cell cycle phase transition
C0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
C0000439cellular_componenttranscription factor TFIIH core complex
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005675cellular_componenttranscription factor TFIIH holo complex
C0006281biological_processDNA repair
C0006289biological_processnucleotide-excision repair
C0006366biological_processtranscription by RNA polymerase II
C0006367biological_processtranscription initiation at RNA polymerase II promoter
C0009755biological_processhormone-mediated signaling pathway
C0045893biological_processpositive regulation of DNA-templated transcription
C0046966molecular_functionnuclear thyroid hormone receptor binding
D0000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
D0000439cellular_componenttranscription factor TFIIH core complex
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005669cellular_componenttranscription factor TFIID complex
D0005675cellular_componenttranscription factor TFIIH holo complex
D0006281biological_processDNA repair
D0006289biological_processnucleotide-excision repair
D0006366biological_processtranscription by RNA polymerase II
D0006367biological_processtranscription initiation at RNA polymerase II promoter
D0016251molecular_functionRNA polymerase II general transcription initiation factor activity
D0016607cellular_componentnuclear speck
E0000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
E0000439cellular_componenttranscription factor TFIIH core complex
E0002031biological_processG protein-coupled receptor internalization
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005669cellular_componenttranscription factor TFIID complex
E0005675cellular_componenttranscription factor TFIIH holo complex
E0006289biological_processnucleotide-excision repair
E0006366biological_processtranscription by RNA polymerase II
E0006367biological_processtranscription initiation at RNA polymerase II promoter
E0009411biological_processresponse to UV
E0016251molecular_functionRNA polymerase II general transcription initiation factor activity
E0016607cellular_componentnuclear speck
F0000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
F0000439cellular_componenttranscription factor TFIIH core complex
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005669cellular_componenttranscription factor TFIID complex
F0005675cellular_componenttranscription factor TFIIH holo complex
F0006281biological_processDNA repair
F0006289biological_processnucleotide-excision repair
F0006366biological_processtranscription by RNA polymerase II
F0006367biological_processtranscription initiation at RNA polymerase II promoter
F0016251molecular_functionRNA polymerase II general transcription initiation factor activity
F0097550cellular_componenttranscription preinitiation complex
G0000439cellular_componenttranscription factor TFIIH core complex
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005669cellular_componenttranscription factor TFIID complex
G0005675cellular_componenttranscription factor TFIIH holo complex
G0005730cellular_componentnucleolus
G0005737cellular_componentcytoplasm
G0006289biological_processnucleotide-excision repair
G0006294biological_processnucleotide-excision repair, preincision complex assembly
G0006366biological_processtranscription by RNA polymerase II
G0006367biological_processtranscription initiation at RNA polymerase II promoter
H0000082biological_processG1/S transition of mitotic cell cycle
H0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
H0000439cellular_componenttranscription factor TFIIH core complex
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005675cellular_componenttranscription factor TFIIH holo complex
H0006281biological_processDNA repair
H0006289biological_processnucleotide-excision repair
H0006357biological_processregulation of transcription by RNA polymerase II
H0006367biological_processtranscription initiation at RNA polymerase II promoter
H0008270molecular_functionzinc ion binding
H0030674molecular_functionprotein-macromolecule adaptor activity
H0043066biological_processnegative regulation of apoptotic process
H0048661biological_processpositive regulation of smooth muscle cell proliferation
H0070516cellular_componentCAK-ERCC2 complex
H0070985cellular_componenttranscription factor TFIIK complex
H2000045biological_processregulation of G1/S transition of mitotic cell cycle
I0000109cellular_componentnucleotide-excision repair complex
I0000404molecular_functionheteroduplex DNA loop binding
I0000405molecular_functionbubble DNA binding
I0000785cellular_componentchromatin
I0003684molecular_functiondamaged DNA binding
I0003697molecular_functionsingle-stranded DNA binding
I0003713molecular_functiontranscription coactivator activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005643cellular_componentnuclear pore
I0005654cellular_componentnucleoplasm
I0005694cellular_componentchromosome
I0005737cellular_componentcytoplasm
I0005886cellular_componentplasma membrane
I0006281biological_processDNA repair
I0006289biological_processnucleotide-excision repair
I0006298biological_processmismatch repair
I0007346biological_processregulation of mitotic cell cycle
I0009410biological_processresponse to xenobiotic stimulus
I0009411biological_processresponse to UV
I0010996biological_processresponse to auditory stimulus
I0043025cellular_componentneuronal cell body
I0044877molecular_functionprotein-containing complex binding
I0045893biological_processpositive regulation of DNA-templated transcription
I0048471cellular_componentperinuclear region of cytoplasm
I0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
I0070914biological_processUV-damage excision repair
I0071942cellular_componentXPC complex
I0072718biological_processresponse to cisplatin
I0090734cellular_componentsite of DNA damage
I0140612molecular_functionDNA damage sensor activity
I1901987biological_processregulation of cell cycle phase transition
I1901990biological_processregulation of mitotic cell cycle phase transition
N0000110cellular_componentnucleotide-excision repair factor 1 complex
N0000715biological_processnucleotide-excision repair, DNA damage recognition
N0003684molecular_functiondamaged DNA binding
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005662cellular_componentDNA replication factor A complex
N0006281biological_processDNA repair
N0006284biological_processbase-excision repair
N0006289biological_processnucleotide-excision repair
N0009650biological_processUV protection
N0016604cellular_componentnuclear body
N0019904molecular_functionprotein domain specific binding
N0034504biological_processprotein localization to nucleus
N0042803molecular_functionprotein homodimerization activity
N0070914biological_processUV-damage excision repair
N1901255biological_processnucleotide-excision repair involved in interstrand cross-link repair
N1990837molecular_functionsequence-specific double-stranded DNA binding
Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues21
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H
ChainResidueDetails
ECYS360-HIS380
site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CgHtLCesCV
ChainResidueDetails
HCYS26-VAL35
site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN
ChainResidueDetails
BALA229-ASN238
site_idPS00752
Number of Residues25
DetailsXPA_1 XPA protein signature 1. CeECgkeFm.DsyLmnhFdlptCdnC
ChainResidueDetails
NCYS105-CYS129
site_idPS00753
Number of Residues17
DetailsXPA_2 XPA protein signature 2. LITKTEaKqEYLLkDcD
ChainResidueDetails
NLEU138-ASP154
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues437
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues3
DetailsMotif: {"description":"DEVH box"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues199
DetailsRegion: {"description":"Mediates interaction with MMS19"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsMotif: {"description":"DEAH box"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues13
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues176
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues34
DetailsZinc finger: {"description":"C4-type"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"A0JN27","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues24
DetailsZinc finger: {"evidences":[{"source":"PubMed","id":"2234061","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D4U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16540648","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

256158

PDB entries from 2026-07-08

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