24VE
Structure of cytosol-open ABCD4-LMBD1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005324 | molecular_function | long-chain fatty acid transmembrane transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005778 | cellular_component | peroxisomal membrane |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006635 | biological_process | fatty acid beta-oxidation |
| A | 0007031 | biological_process | peroxisome organization |
| A | 0009235 | biological_process | cobalamin metabolic process |
| A | 0015420 | molecular_function | ABC-type vitamin B12 transporter activity |
| A | 0015889 | biological_process | cobalamin transport |
| A | 0015910 | biological_process | long-chain fatty acid import into peroxisome |
| A | 0016020 | cellular_component | membrane |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0042760 | biological_process | very long-chain fatty acid catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005324 | molecular_function | long-chain fatty acid transmembrane transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005777 | cellular_component | peroxisome |
| B | 0005778 | cellular_component | peroxisomal membrane |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006635 | biological_process | fatty acid beta-oxidation |
| B | 0007031 | biological_process | peroxisome organization |
| B | 0009235 | biological_process | cobalamin metabolic process |
| B | 0015420 | molecular_function | ABC-type vitamin B12 transporter activity |
| B | 0015889 | biological_process | cobalamin transport |
| B | 0015910 | biological_process | long-chain fatty acid import into peroxisome |
| B | 0016020 | cellular_component | membrane |
| B | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| B | 0042760 | biological_process | very long-chain fatty acid catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005158 | molecular_function | insulin receptor binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005764 | cellular_component | lysosome |
| C | 0005765 | cellular_component | lysosomal membrane |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0007369 | biological_process | gastrulation |
| C | 0015420 | molecular_function | ABC-type vitamin B12 transporter activity |
| C | 0015889 | biological_process | cobalamin transport |
| C | 0016020 | cellular_component | membrane |
| C | 0030136 | cellular_component | clathrin-coated vesicle |
| C | 0032050 | molecular_function | clathrin heavy chain binding |
| C | 0035461 | biological_process | vitamin transmembrane transport |
| C | 0035612 | molecular_function | AP-2 adaptor complex binding |
| C | 0038016 | biological_process | insulin receptor internalization |
| C | 0045334 | cellular_component | clathrin-coated endocytic vesicle |
| C | 0061462 | biological_process | protein localization to lysosome |
| C | 0072583 | biological_process | clathrin-dependent endocytosis |
| C | 0090482 | molecular_function | vitamin transmembrane transporter activity |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSPGEMQRLSFARLF |
| Chain | Residue | Details |
| A | LEU524-PHE538 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 200 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 586 |
| Details | Domain: {"description":"ABC transmembrane type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 428 |
| Details | Domain: {"description":"ABC transporter","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 135 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 28 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 3 |
| Details | Motif: {"description":"YERL motif; mediates interaction with adapter protein complex 2 and is essential for its function in clathrin-mediated endocytosis of INSR","evidences":[{"source":"UniProtKB","id":"Q8K0B2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | Motif: {"description":"WTKF motif; mediates interaction with adapter protein complex 2 and is essential for its function in clathrin-mediated endocytosis of INSR","evidences":[{"source":"UniProtKB","id":"Q8K0B2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q8K0B2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
